Prognostic value of CD166 expression in cancers of the digestive system: a systematic review and meta-analysis.
Prognostic value of CD166 expression in cancers of the digestive system: a systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0070958
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Xu AX
中科院分区：
文献类型：
--
作者：
Ni C;Zhang Z;Zhu X;Liu Y;Qu D;Wu P;Huang J;Xu AX
许多研究报道了CD166作为消化系统癌症干细胞标记物的预后预测价值；然而，其预测价值仍然存在争议。在这里，我们用荟萃分析的方法研究了消化系统肿瘤中CD166阳性表达与临床病理特征的相关性。对截至2013年3月的PubMed和ISI Web of Science进行全面搜索。仅收录了胰腺癌、食道癌、胃癌和结直肠癌等消化系统肿瘤中CD166抗原免疫组织化学染色的文章。收集比较3年和5年总存活率以及其他临床病理特征的数据。符合纳入标准的2,553名患者的9项研究被纳入分析。CD166免疫组织化学染色中位数为56%(25.4%~76.3%)。在结直肠癌中，固定效应模型结果显示CD166阳性表达是一个独立的标记物，与较小的肿瘤负担(T类；RR = 为0.93，95%，CI：0.88~0.98)相关，但较差的转移至邻近淋巴结(N类；RR = 为1.17，95%CI：1.05~1.30)。CD166胞浆阳性表达与5年总生存率呈正相关(RR = 为1.4795%1.21~1.79)，但与3年或5年总生存率无明显相关性。根据已发表的研究，CD166的不同细胞位置具有不同的预后价值，胞浆阳性表达与预后不良相关。此外，我们的结果还发现，CD166的表达在结直肠癌中特异性地提示晚期T类和N阳性状态。
Many studies have reported the prognostic predictive value of CD166 as a cancer stem cell marker in cancers of the digestive system; however, its predictive value remains controversial. Here, we investigate the correlation between CD166 positivity in digestive system cancers and clinicopathological features using meta-analysis. A comprehensive search in PubMed and ISI Web of Science through March of 2013 was performed. Only articles containing CD166 antigen immunohistochemical staining in cancers of the digestive system were included,including pancreatic cancer, esophageal cancer, gastric cancer and colorectal cancer. Data comparing 3- and 5-year overall survival along with other clinicopathological features were collected. Nine studies with 2553 patients who met the inclusion criteria were included for the analysis. The median rate of CD166 immunohistochemical staining expression was 56% (25.4%–76.3%). In colorectal cancer specifically, the results of a fixed-effects model indicated that CD166-positive expression was an independent marker associated with a smaller tumor burden (T category; RR = 0.93, 95%, CI: 0.88–0.98) but worse spread to nearby lymph nodes (N category; RR = 1.17, 95% CI: 1.05–1.30). The 5-year overall survival rate was showed relationship with cytoplasmic positive staining of CD166 (RR = 1.47 95% 1.21–1.79), but no significant association was found in the pool or any other stratified analysis with 3- or 5- year overall survival rate. Based on the published studies, different cellular location of CD166 has distinct prognostic value and cytoplasmic positive expression is associated with worse prognosis outcome. Besides, our results also find CD166 expression indicate advanced T category and N-positive status in colorectal cancer specifically.
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