Recent developments in latex allergy
Recent developments in latex allergy
复制标题
乳胶过敏的最新进展
DOI：
--
复制
发表时间：
2002
影响因子：
2.8
通讯作者：
T. Palosuo
中科院分区：
文献类型：
--
作者：
K. Turjanmaa;H. Alenius;T. Reunala;T. Palosuo
综述目的天然胶乳的速发型过敏反应仍然是一个重要的医学和职业健康问题。在这篇综述中，我们重点了解天然胶乳过敏的职业暴露和流行病学，危险人群，诊断和预防的意义所取得的进展。我们还讨论了旨在量化临床相关的天然橡胶胶乳过敏原和主要天然橡胶胶乳过敏原的B细胞表位的研究方法。最近的发现已经发表了一些前瞻性研究，重点是预防天然橡胶胶乳过敏。几个研究小组继续努力鉴定和表征新的天然橡胶胶乳过敏原。在旨在改善天然橡胶胶乳过敏的诊断以及开发用于测量特定天然橡胶胶乳过敏原的定量方法的研究中，评估了重组DNA技术产生的纯化过敏原或蛋白质的使用。第一次，构象免疫球蛋白E表位被确定在一个主要的天然橡胶胶乳过敏原，hevein，使用一种新的嵌合体为基础的过敏原表位作图策略。总结在卫生保健中采取的减少天然橡胶胶乳产品暴露的措施似乎可以有效减少新致敏反应的数量。一些新的轻微的天然橡胶胶乳过敏原，可能是重要的过敏原交叉反应，被确定，和一些非医用天然橡胶胶乳产品被发现是潜在的危险天然橡胶胶乳过敏患者。一些实验室开发了灵敏和特异的免疫测定法，用于定量测定制成品中临床相关的天然橡胶胶乳过敏原。这些测定可能最终取代非特异性总蛋白测量，目前提倡由卫生当局在天然橡胶胶乳产品中的过敏原量的间接估计。主要过敏原的构象免疫球蛋白结合B细胞表位的知识预计将有助于设计最佳的特异性免疫治疗试剂。
Purpose of reviewImmediate allergic reactions to natural rubber latex continue to be an important medical and occupational health problem. In this review we focus on progress made in understanding the significance of occupational exposure and epidemiology, risk groups, diagnosis and prevention of natural rubber latex allergy. We also discuss methods aimed at quantification of clinically relevant natural rubber latex allergens and studies on B-cell epitopes of major natural rubber latex allergens. Recent findingsProspective studies have been published focusing on the prevention of natural rubber latex allergy. Efforts to identify and characterize new natural rubber latex allergens were continued in several research groups. The use of purified allergens or proteins produced by recombinant DNA technology was assessed in studies aimed at improving the diagnosis of natural rubber latex allergy as well as in developing quantitative methods for the measurement of specific natural rubber latex allergens. For the first time, conformational immunoglobulin E epitopes were identified in a major natural rubber latex allergen, hevein, using a novel chimera-based allergen epitope mapping strategy. SummaryMeasures taken in health care to reduce exposure to natural rubber latex products seem to be effective in reducing the number of new sensitizations. A few new minor natural rubber latex allergens, probably important in allergen cross reactions, were identified, and some nonmedical natural rubber latex products were found to be potentially dangerous to natural rubber latex-allergic patients. Sensitive and specific immunoassays for quantification of clinically relevant natural rubber latex allergens in manufactured products were developed in some laboratories. These assays may eventually replace the nonspecific total protein measurement, currently advocated by health authorities in the indirect estimation of allergen amounts in natural rubber latex products. Knowledge about conformational immunoglobulin-binding B-cell epitopes of major allergens is expected to be helpful in designing optimal reagents to specific immunotherapy.