ISLET-CELL ANTIBODIES IN DIABETES-MELLITUS WITH AUTOIMMUNE POLY-ENDOCRINE DEFICIENCIES
ISLET-CELL ANTIBODIES IN DIABETES-MELLITUS WITH AUTOIMMUNE POLY-ENDOCRINE DEFICIENCIES
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DOI：
10.1016/s0140-6736(74)90140-8
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发表时间：
1974-01-01
期刊：
影响因子：
168.9
通讯作者：
DONIACH, D
中科院分区：
文献类型：
--
作者：
BOTTAZZO, GF;FLORINCH.A;DONIACH, D
免疫荧光法在13例多内分泌缺陷伴器官特异性自身免疫患者血清中发现胰岛细胞抗体。其中10例患者为糖尿病患者。抗体是补体固定的，IgG类;滴度从1到160不等，与胰岛素治疗无关。器官特异性胰腺抗体的存在支持了糖尿病自身免疫形式的假设，提出了解释在这种疾病的选定病例中发现的组织学“胰岛炎“。这种新的标记物可以将胰岛素依赖型糖尿病的同质群体分离出来，这些人很可能被证明具有与其他形式的遗传性糖尿病不同的代谢模式。
Antibodies to pancreatic islet cells were found by immunofluorescence in the sera of 13 patients with multiendocrine deficiencies associated with organ-specific autoimmunity. 10 of these patients were diabetic. The antibodies were complement fixing and of IgG class; titres varied from 1 to 160 and were independent of insulin treatment. The presence of organ-specific pancreatic antibodies supports the hypothesis of an autoimmune form of diabetes mellitus put forward to explain the histological " insulitis " found in selected cases of this disease. This new marker allows the segregation of a homogeneous group of insulin-dependent diabetics who may well prove to have a different metabolic pattern from that in other forms of inherited diabetes mellitus.