Fetal anterior abdominal wall thickness in diabetic pregnancy
Fetal anterior abdominal wall thickness in diabetic pregnancy
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DOI：
10.1016/j.ejogrb.2008.02.021
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发表时间：
2008-09-01
期刊：
影响因子：
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通讯作者：
McAuliffe, Fionnuala M.
中科院分区：
文献类型：
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作者：
Higgins, Mary F.;Russell, Noirin M.;McAuliffe, Fionnuala M.
目的：本研究的目的是调查是否在妊娠晚期糖尿病胎儿前腹壁（AAW）厚度反映血糖控制和预测macrosymia.Study设计：前瞻性队列研究在三级产科单位。125名糖尿病母亲（71名妊娠前和54名妊娠期糖尿病患者接受胰岛素治疗）接受常规系列妊娠晚期超声检查，并额外测量AAW厚度。结果：在妊娠30 ~ 38周的糖尿病妊娠中，共记录了335例胎儿AAW测量值。巨大儿的妊娠晚期AAW显著更高（5.4 +/- 1.4 mm vs. 4.7 +/- 1.4 mm，p < 0.05）。预测巨大儿的AAW ROC截断值分别为孕30周3.5 mm、孕33周4.5 mm和孕36周5.5 mm。使用升高的AAW测量或AC >第90百分位数，出生体重大于第90百分位数的预测（88%）优于单独AC（70%）。这种改善的敏感性，甚至在早期妊娠在第三trimester.Conclusion：测量AAW糖尿病妊娠可能有巨大儿的预测中的作用。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Objective: The purpose of this study was to investigate whether third trimester fetal anterior abdominal wall (AAW) thickness in diabetic pregnancy reflects glycaemic control and predicts macrosomia.Study design: Prospective cohort study in a tertiary level maternity unit. One hundred and twenty-five diabetic mothers (71 pre-gestational and 54 gestational diabetics on insulin) underwent routine serial third trimester ultrasound examination with the additional measurement of AAW thickness. Pregnancy outcome was obtained.Results: 335 fetal AAW measurements were recorded in diabetic pregnancy from 30 to 38 weeks gestation. Third trimester AAW was significantly higher in macrosomic babies (5.4 +/- 1.4 mm vs. 4.7 +/- 1.4 mm, p < 0.05). ROC derived cut off for AAW in the prediction of macrosomia was 3.5 mm at 30 weeks, 4.5 mm at 33 weeks and 5.5 mm at 36 weeks gestation. Using either a raised AAW measurement or an AC > 90th centile, the prediction of birth weight greater than the 90th centile was better (88%) than with AC alone (70%). This improvement in sensitivity held even at earlier gestations in the third trimester.Conclusion: Measurement of AAW in diabetic pregnancy may have a role in the prediction of macrosomia. (C) 2008 Elsevier Ireland Ltd. All rights reserved.