Open-label study of high (30 mg) and moderate (20 mg) dose escitalopram for the treatment of obsessive-compulsive disorder
Open-label study of high (30 mg) and moderate (20 mg) dose escitalopram for the treatment of obsessive-compulsive disorder
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DOI：
10.1097/yic.0b013e32833119d8
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发表时间：
2009-11-01
影响因子：
2.6
通讯作者：
Keuthen, Nancy J.
中科院分区：
文献类型：
--
作者：
Dougherty, Darin D.;Jameson, Mariko;Keuthen, Nancy J.
本研究旨在探讨不同剂量的艾司西酞普兰治疗强迫症（OCD）的功效。 30 名受试者参加了一项为期 16 周的艾司西酞普兰开放标签试验，并随机分配到 20 毫克或 30 毫克研究组。在基线和第 2、4、8、12 和 16 周进行了评估强迫症症状、焦虑、抑郁和生活质量的研究措施。对于 23 名完成研究的人，治疗前和治疗后分析显示显着改善（P
This study sought to investigate the efficacy of escitalopram at different dosages for the treatment of obsessive-compulsive disorder (OCD). Thirty individuals were enrolled in a 16-week, open-label trial of escitalopram and randomly assigned to the 20 or 30 mg study arm. Study measures assessing OCD symptoms, anxiety, depression, and quality of life were administered at baseline and weeks 2, 4, 8, 12, and 16. For the 23 study completers, pretreatment and posttreatment analyses revealed significant improvements (P