Corticotectal circuit in the cat: a functional analysis of the lateral geniculate nucleus layers of origin.
Corticotectal circuit in the cat: a functional analysis of the lateral geniculate nucleus layers of origin.
复制标题
猫的皮质顶盖回路：外侧膝状体核起源层的功能分析。
DOI：
10.1152/jn.1988.59.6.1783
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发表时间：
1988
影响因子：
2.5
通讯作者：
Colby,CL
中科院分区：
文献类型：
--
作者：
Colby,CL
1.猫的背外侧膝状体核（LGN）是视网膜与几个视觉皮层区域之间的主要丘脑中继。这些皮质区又投射到上级丘（SC）。本实验的目的是确定哪些LGN层提供了必要的输入皮质顶盖电路。2.在记录上级丘视网膜定位相应部分的视觉反应过程中，通过微量注射氯化钴使LGN的各个层可逆地失活。3.对于通过对侧眼驱动的细胞，A层或内侧层间核（MIN）的失活对上级丘的视觉反应性几乎没有影响。与此相反，失活层C废除视觉反应在四分之一的SC记录网站，减少在另一个季度的反应，并留下一半的记录网站不受影响。4.对于通过同侧眼驱动的细胞，C1层或MIN的失活没有影响。层A1的失活均匀地降低了上级丘的视觉反应，通常完全取消。5.这些结果是兼容与以前的工作表明，皮质输入SC起源于Y细胞。它们表明，五个Y细胞层中的两个（A1和C）为皮质-顶盖回路提供主要输入。结果表明，层A1在功能上与层C以及层A相似。
1. The dorsal lateral geniculate nucleus (LGN) of the cat is a major thalamic relay between the retina and several visual cortical areas. These cortical areas in turn project to the superior colliculus (SC). The aim of the present experiment was to determine which LGN layers provide a necessary input to the corticotectal circuit. 2. Individual layers of the LGN were reversibly inactivated by microinjection of cobalt chloride during recording of visual responses in the retinotopically corresponding part of the superior colliculus. 3. For cells driven through the contralateral eye, inactivation of layer A or the medial interlaminar nucleus (MIN) had little effect on visual responsiveness in the superior colliculus. In contrast, inactivation of layer C abolished visual responses at one-quarter of the SC recording sites, reduced responses at another quarter, and left half of the recording sites unaffected. 4. For cells driven through the ipsilateral eye, inactivation of layer C1 or the MIN had no effect. Inactivation of layer A1 uniformly reduced visual responses in the superior colliculus and usually abolished them entirely. 5. These results are compatible with previous work showing that cortical input to the SC originates from Y-cells. They indicate that two of the five Y-cell containing layers (A1 and C) provide major inputs to the corticotectal circuit. The results suggest that layer A1 is functionally allied to layer C as well as to layer A.