Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
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DOI:
10.1093/hmg/ddy327
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发表时间:
2019-01-01
影响因子:
3.5
通讯作者:
Lindgren CM
Lindgren CM
中科院分区:
生物学2区
文献类型:
--
作者:
Pulit SL;Stoneman C;Morris AP;Wood AR;Glastonbury CA;Tyrrell J;Yengo L;Ferreira T;Marouli E;Ji Y;Yang J;Jones S;Beaumont R;Croteau-Chonka DC;Winkler TW;GIANT Consortium;Hattersley AT;Loos RJF;Hirschhorn JN;Visscher PM;Frayling TM;Yaghootkar H;Lindgren CM

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全世界超过三分之一的成年人超重或肥胖。流行病学研究表明,多余脂肪的位置和分布,而不是一般的肥胖,更能预测肥胖后遗症的风险,包括心脏代谢疾病和癌症。我们对体脂分布进行了全基因组关联研究荟萃分析,通过调整体重指数(WHRadjBMI)的腰臀比(WHR)进行测量,并在346个位点中确定了463个信号。遗传性和变异效应在女性中普遍比男性强,我们发现大约三分之一的信号是性二态的。携带最多WHRadjBMI增加等位基因的5%个体的WHR高于代谢综合征阈值的可能性是底部5%的1.62倍。这些公开的数据将为身体脂肪分布及其与疾病的关系提供生物学信息。
More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, are more informative for predicting risk of obesity sequelae, including cardiometabolic disease and cancer. We performed a genome-wide association study meta-analysis of body fat distribution, measured by waist-to-hip ratio (WHR) adjusted for body mass index (WHRadjBMI), and identified 463 signals in 346 loci. Heritability and variant effects were generally stronger in women than men, and we found approximately one-third of all signals to be sexually dimorphic. The 5% of individuals carrying the most WHRadjBMI-increasing alleles were 1.62 times more likely than the bottom 5% to have a WHR above the thresholds used for metabolic syndrome. These data, made publicly available, will inform the biology of body fat distribution and its relationship with disease.
腰围比与心脏代谢性状,2型糖尿病和冠状动脉疾病的遗传关联。
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