Effects of flurbiprofen on the progression of periodontitis in Macaca mulatta.
Effects of flurbiprofen on the progression of periodontitis in Macaca mulatta.
复制标题
氟比洛芬对猕猴牙周炎进展的影响。
DOI：
10.1111/j.1600-0765.1987.tb02058.x
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发表时间：
1987
影响因子：
3.5
通讯作者：
Odle,BM
中科院分区：
文献类型：
--
作者：
Offenbacher,S;Braswell,LD;Loos,AS;Johnson,HG;Hall,CM;McClure,H;Orkin,JL;Strobert,EA;Green,MD;Odle,BM
在恒河猴（Macaca mulatta）的结扎诱导和自发性牙周炎模型中研究了非甾体抗炎药氟比洛芬的作用。将患有初期牙周炎的24只成年猴分为3个疾病匹配组。两组分别接受氟比洛芬酯0.27 mg/kg/d或7.1 mg/kg/d，通过渗透压微泵全身给药。使用裂口法，在一侧放置结扎线，并定期监测牙周炎的进展，持续6个月。临床测量包括标准化X线片、Ramfjord附着水平测定和探测时发红、水肿和出血的评估。在6个月时，氟比洛芬治疗的动物中，结扎诱导的和自发性牙周炎的附着丧失（p <0.05）、牙龈发红（p <0.05）和探诊出血（p < 0.05）在统计学上显著抑制。8只结扎对照猴中有8只丧失显著附着（平均丧失1.06 mm/部位）。在15只接受氟比洛芬治疗的结扎猴中，只有3只丧失了任何显著的附着，总体平均丢失为0.34 mm/部位，显著低于对照组的丢失1.06 mm/部位（p = 4.46 × 10 - 3）。与接受氟比洛芬治疗的队列猴组相比，对照结扎猴在6个月内发生显著附着丧失的几率升高了29.3倍。与对照猴相比，氟比洛芬治疗还显著抑制了6个月的自发性附着丧失，p < 0.05。这些数据为环氧合酶产物在牙周病进展中的中心作用提供了进一步的证据。氟比洛芬酯抑制牙周附着丧失的能力，即使在存在总斑块积累的情况下，对氟比洛芬酯作为牙周炎治疗方式的潜在用途具有重要意义。
The effect of the nonsteroidal anti‐inflammatory drug flurbiprofen has been studied in the ligature‐induced and spontaneous periodontitis model in the rhesus monkey,Macaca mulatta.Twenty‐four adult monkeys with incipient periodontitis were divided into three disease‐matched groups. Two groups received flurbiprofen at dosages of either 0.27 mg/kg/d or 7.1 mg/kg/d delivered systemically via osmotic minipump. A split‐mouth approach was used, placing ligatures on one side and monitoring the progression of periodontitis at regular intervals for 6 months. Clinical measurements included standardized radiographs, Ramfjord attachment level determinations and assessments of redness, edema and bleeding on probing. There was a statistically significant inhibition of attachment loss (p < 0.05), gingival redness (p < 0.05) and bleeding on probing (p < 0.05) in ligatureinduced and spontaneous periodontitis in the flurbiprofen‐treated animals at 6 months. Eight of 8 ligated control monkeys lost significant attachment (mean loss of 1.06 mm/site). Only 3 of 15 flurbiprofen‐treated ligated monkeys lost any significant attachment, with an overall mean loss of 0.34 mm/site, which was significantly less than the control loss of 1.06 mm/site at p = 4.46 times 10‐3.The odds of a control ligated monkey undergoing significant attachment loss in 6 months are elevated 29.3‐fold, as compared to the flurbiprofen‐treated, cohort monkey group. Flurbiprofen treatment also significantly inhibited spontaneous attachment loss for 6 months as compared to control monkeys, at p < 0.05. These data provide further evidence for the central role of cyclooxygenase products in the progression of periodontal disease. The ability of flurbiprofen to inhibit periodontal attachment loss, even in the presence of gross plaque accumulation, has significant implications for the potential use of flurbiprofen as an adjunctive periodontal therapeutic modality.