Transcriptional and epigenetic control of hematopoietic stem cell fate decisions in vertebrates
Transcriptional and epigenetic control of hematopoietic stem cell fate decisions in vertebrates
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DOI：
10.1016/j.ydbio.2021.03.003
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发表时间：
2021-05-04
影响因子：
2.7
通讯作者：
Liu, Feng
中科院分区：
文献类型：
--
作者：
Ding, Yanyan;Liu, Zhenxin;Liu, Feng
造血干细胞（HSC）是成人造血的基础，可产生所有类型的成熟血统。在脊椎动物中，HSC 的发育是一个逐步的过程，由染色质结构以及一组转录和表观遗传调节因子协调调节。更深入地了解控制 HSC 生成、扩增和功能的分子机制，为临床应用的体外可移植 HSC 生成和扩增带来了巨大希望。本研究回顾了脊椎动物造血干细胞命运决定的转录和表观遗传控制的最新进展。
Hematopoietic stem cells (HSCs) are the foundation of adult hematopoiesis that produce all types of mature blood lineages. In vertebrates, HSC development is a stepwise process, coordinately regulated by chromatin architectures and a group of transcriptional and epigenetic regulators. A deeper understanding of the molecular mechanisms governing the generation, expansion, and function of HSCs holds great promise in the generation and expansion of engraftable HSCs in vitro for clinical applications. This study reviewed recent advances in transcriptional and epigenetic control of hematopoietic stem cell fate decisions in vertebrates.