Gastrointestinal tract modelling in health and disease
Gastrointestinal tract modelling in health and disease
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DOI：
10.3748/wjg.15.169
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发表时间：
2009-01-14
影响因子：
4.3
通讯作者：
Gregersen, Hans
中科院分区：
文献类型：
--
作者：
Liao, Dong-Hua;Zhao, Jing-Bo;Gregersen, Hans
胃肠道（GI）是多细胞动物体内的器官系统，它吸收食物，吸收食物以提取能量和营养，并排出剩余的废物。胃肠道功能的各种模式是由多种组织和细胞类型的综合行为产生的。对胃肠道的彻底研究需要了解健康和疾病中细胞，组织和胃肠道器官之间的相互作用。这不仅取决于对许多细胞离子电流机制和信号转导途径的了解，而且取决于对大规模GI组织结构和神经网络的特殊分布的了解。应对这种复杂性爆炸的一种独特方法是数学和计算建模;为人类胃肠道解剖学和生理学的多级建模和模拟提供了一个计算框架。这篇综述的目的是描述人类和动物胃肠道的生物力学建模工作的现状，这些工作可以进一步用于整合胃肠道系统的生理学、解剖学和医学知识。这种建模将有助于研究，并确保医疗专业人员受益，通过提供有关患者病情和动物疾病模型中GI重塑的相关和精确信息。它还将提高医疗程序的准确性和效率，从而降低诊断和治疗费用。(c)2009 WJG出版社和百世登。All rights reserved.
The gastrointestinal (GI) tract is the system of organs within multi-cellular animals that takes in food, digests it to extract energy and nutrients, and expels the remaining waste. The various patterns of GI tract function are generated by the integrated behaviour of multiple tissues and cell types. A thorough study of the GI tract requires understanding of the interactions between cells, tissues and gastrointestinal organs in health and disease. This depends on knowledge, not only of numerous cellular ionic current mechanisms and signal transduction pathways, but also of large scale GI tissue structures and the special distribution of the nervous network. A unique way of coping with this explosion in complexity is mathematical and computational modelling; providing a computational framework for the multilevel modelling and simulation of the human gastrointestinal anatomy and physiology. The aim of this review is to describe the current status of biomechanical modelling work of the GI tract in humans and animals, which can be further used to integrate the physiological, anatomical and medical knowledge of the GI system. Such modelling will aid research and ensure that medical professionals benefit, through the provision of relevant and precise information about the patient's condition and GI remodelling in animal disease models. It will also improve the accuracy and efficiency of medical procedures, which could result in reduced cost for diagnosis and treatment. (c) 2009 The WJG Press and Baishideng. All rights reserved.