OSTEOCONDUCTIVE PROPERTIES OF METHYLPYRROLIDINONE CHITOSAN IN AN ANIMAL-MODEL
OSTEOCONDUCTIVE PROPERTIES OF METHYLPYRROLIDINONE CHITOSAN IN AN ANIMAL-MODEL
复制标题
DOI：
10.1016/0142-9612(93)90134-n
复制
发表时间：
1993-10-01
期刊：
影响因子：
14
通讯作者：
CASTALDINI, C
中科院分区：
文献类型：
--
作者：
MUZZARELLI, RAA;ZUCCHINI, C;CASTALDINI, C
用冻干甲基吡咯烷酮壳聚糖治疗兔胫骨骨缺损。手术后60天的组织学观察显示，与对照组相比，大量新生骨组织来自于原有骨和骨膜。壳聚糖甲基吡咯烷酮的阳离子性质和螯合能力明显有利于矿化。在凝固-多糖混合物中包裹的生长因子的刺激下，骨内-骨膜和骨髓成骨细胞样前体产生膜内骨形成。超微结构检查证实骨样骨后组织矿化。
Bone defects were surgically produced in the tibiae of rabbits and medicated with freeze-dried methylpyrrolidinone chitosan. Histological observations 60d after surgery showed a considerable presence of neoformed bone tissue, as opposed to controls, originating from the pre-existing bone as well as from the periosteum. The cationic nature and the chelating ability of the methylpyrrolidinone, chitosan apparently favoured mineralization. Endosteal-periosteal and bone marrow osteoblast-like precursors, stimulated by growth factors entrapped in the coagulum-polysaccharide mixture, gave rise to intramembranous bone formation. The ultrastructural examination evidenced that bone osteoid was followed by mineralization of the tissue.