Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2, diabetes mellitus in middle-aged Chinese women
Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2, diabetes mellitus in middle-aged Chinese women
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DOI：
10.1001/archinte.167.21.2310
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发表时间：
2007-11-26
影响因子：
--
通讯作者：
Shu, Xiao Ou
中科院分区：
文献类型：
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作者：
Villegas, Raquel;Liu, Simin;Shu, Xiao Ou
背景：关于膳食血糖指数和血糖负荷在2型糖尿病发展中的作用存在许多不确定性，特别是在传统上以高碳水化合物饮食为生的人群中。方法：我们对64227名基线时无糖尿病或其他慢性疾病史的中国女性进行了4.6年的观察。使用有效的问卷进行面对面访谈，收集饮食习惯、身体活动和其他相关信息的数据。通过面对面随访确定偶发糖尿病病例。使用多变量Cox比例风险模型评估饮食碳水化合物摄入量、血糖指数和血糖负荷与糖尿病发病率之间的关系。结果：在297755人年的随访中，我们发现了1608例2型糖尿病病例。饮食中碳水化合物的摄入和大米的消耗与患2型糖尿病的风险呈正相关。碳水化合物摄入量最高和最低五分位数的相对危险度经多变量调整后的估计值为1.28(95%可信区间，1.09-1.50)，大米摄入量为1.78（95%可信区间，1.48-2.15）。饮食血糖指数增加五分位数的相对危险度为1.00、1.04、1.02、1.09和1.21(95%可信区间为1.03-1.43)，饮食血糖负荷增加五分位数的相对危险度为1.00、1.06、0.97、1.23和1.34（95%可信区间为1.13-1.58）。结论：高血糖指数食物的大量摄入和。血糖负荷，特别是大米，这一人群中主要的碳水化合物食物，可能增加中国妇女患2型糖尿病的风险。
Background: Much uncertainty exists about the role of dietary glycemic index and glycemic load in the development of type 2 diabetes mellitus, especially in populations that traditionally subsist on a diet high in carbohydrates.Methods: We observed a cohort of 64227 Chinese women with no history of diabetes or other chronic disease at baseline for 4.6 years. In-person interviews were conducted to collect data on dietary habits, physical activity, and other relevant information using a validated questionnaire. Incident diabetes cases were identified via in-person follow-up. Associations between dietary carbohydrate intake, glycemic index, and glycemic load and diabetes incidence were evaluated using multivariable Cox proportional hazards models.Results: We identified 1608 incident cases of type 2 diabetes mellitus in 297755 person-years of follow-up. Dietary carbohydrate intake and consumption of rice were positively associated with risk of developing type 2 diabetes mellitus. The multivariable-adjusted estimates of relative risk comparing the highest vs the lowest quintiles of intake were 1.28 (95% confidence interval, 1.09-1.50) for carbohydrates and 1.78 (95% confidence interval, 1.48-2.15) for rice. The relative risk for increasing quintiles of intake was 1.00, 1.04, 1.02, 1.09, and 1.21 (95% confidence interval, 1.03-1.43) for dietary glycemic index and 1.00, 1.06, 0.97, 1.23, and 1.34 (95% confidence interval, 1.13-1.58) for dietary glycemic load.Conclusion: High intake of foods with a high glycemic index and. glycemic load, especially rice, the main carbohydrate-contributing food in this population, may increase the risk of type 2 diabetes mellitus in Chinese women.