A MODEL OF ELECTRICAL EXCITATION OF THE MAMMALIAN AUDITORY-NERVE NEURON
A MODEL OF ELECTRICAL EXCITATION OF THE MAMMALIAN AUDITORY-NERVE NEURON
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DOI：
10.1016/0378-5955(87)90197-3
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发表时间：
1987-01-01
期刊：
影响因子：
2.8
通讯作者：
PARKINS, CW
中科院分区：
文献类型：
--
作者：
COLOMBO, J;PARKINS, CW
基于Frankenhauser和Huxley的经典工作[（1964）J.Physiol.171，302-315]，由McNeal修改[（1976）IEEE Trans. Biomed. Eng. BME-23，329-336]和Reilly等人[（1985）IEEE Trans.Biomed. Eng. BME-32，1001-1011]，并微调以表示从松鼠猴中的单神经纤维实验获得的生理数据。该模型能够再现电刺激引起的神经动作电位波形，并能够可靠地预测动作电位阈值和强度-持续时间曲线。本文解释了数学模型的推导和改变某些独立参数的影响，包括纤维直径，长度的节点的Ranvier，节间长度，髓鞘厚度。根据Liberman和奥利弗的解剖学发现选择模型参数[（1984）J. Comp. Neurol. 223，163-176]，and Liberman（J. Commun.）.氨基糖苷类药物对内耳造成损伤后，内耳神经的无髓终末存活的长度还没有实验确定。因此，将其作为模型中的自变量进行研究。发现10.0 μ m的无髓鞘末端长度最准确地描述了从氨基糖苷类药物处理的松鼠猴获得的实验神经强度-持续时间曲线。对模型具有第二大显著影响的参数是纤维直径，其影响穿过膜和穿过纤维的所有传导路径。最后，将模型的结果与植入人工耳蜗的患者和猴子的行为数据进行比较。1987年，《听》（Hear）。Res. 31，267-286]的模型的预测进行定量比较与单神经元数据从松鼠猴。
A model of the mammalian auditory-nerve neuron has been developed based on the classical work of Frankenhauser and Huxley [(1964) J. Physiol. 171, 302-315], modified by McNeal [(1976) IEEE Trans. Biomed. Eng. BME-23, 329-336], and Reilly et al. [(1985) IEEE Trans. Biomed. Eng. BME-32, 1001-1011], and fine tuned to represent physiological data obtained from single auditory-nerve fiber experiments in squirrel monkeys. The model is capable of reproducing neural action potential waveforms due to electrical stimulation, and can reliably predict action potential thresholds and strength-duration curves. This paper explains the derivation of the mathematical model and the effects of varying certain independent parameters including fiber diameter, length of the nodes of Ranvier, internodal length, and myelin thickness. The model parameters were selected according to the anatomical findings of Liberman and Oliver [(1984) J. Comp. Neurol. 223, 163-176], and Liberman (Pers. Commun.). The length of the unmyelinated termination of the auditory-nerve that survives after aminoglycoside damage to the inner ear has not been experimentally determined. Therefore, it was investigated as an independent variable in the model. An unmyelinated terminal length of 10.0 .mu.m was found to most accurately describe the experimental neural strength-duration curves obtained from aminoglycoside-deafened squirrel monkeys. The parameter that had the next most significant effect on the model was fiber diameter which affects all conduction pathways, across the membrane and through the fiber. Finally the results of the model are compared with behavioral data obtained from patients and monkeys implanted with cochlear prostheses. In the companion paper [(1987) Hear. Res. 31, 267-286] predictions of the model are quantitatively compared with single-neuron data from squirrel monkeys.