MOLECULAR-STRUCTURE OF A SOMATICALLY UNSTABLE TRANSPOSABLE ELEMENT IN DROSOPHILA
MOLECULAR-STRUCTURE OF A SOMATICALLY UNSTABLE TRANSPOSABLE ELEMENT IN DROSOPHILA
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DOI：
10.1073/pnas.83.22.8684
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发表时间：
1986-11-01
影响因子：
11.1
通讯作者：
HARTL, DL
中科院分区：
文献类型：
--
作者：
JACOBSON, JW;MEDHORA, MM;HARTL, DL
一个转座因子已经从黑腹果蝇的姊妹种毛里求斯果蝇的一个不稳定的白色突变中分离出来。不稳定的白桃（wpch）等位基因表现出一系列的生殖系和体细胞突变更类似于插入突变在玉米和线虫的插入突变比已报道的果蝇中的插入突变。插入元件mariner长1286个核苷酸，末端有反向重复序列。该元件含有编码346个氨基酸的单个开放阅读框。在插入位点存在白色序列的2个碱基对的重复。水手是目前在大约20份在D。mauritiana的基因组中存在0 - 7个拷贝，而D.黑腹果蝇
A transposable element has been isolated from an unstable white mutation in Drosophila mauritiana, a sibling species of Drosophila melanogaster. The unstable white-peach (wpch) allele exhibits a spectrum of germ-line and somatic mutability more similar to insertion mutations in maize and in the nematode Caenorhabditis elegans than has been reported for insertion mutations in Drosophila. The inserted element mariner is 1286 nucleotides long and has terminal inverted repeats. The element contains a single open reading frame encoding 346 amino acids. A duplication of 2 base pairs of white sequence is present at the insertion site. Mariner is present in approximately 20 copies in the D. mauritiana genome, is present from 0 to 7 copies in other members of the sibling species group, and is apparently absent from the genome of D. melanogaster.