ANTIOXIDANT ACTIVITY OF CARNOSINE, HOMOCARNOSINE, AND ANSERINE PRESENT IN MUSCLE AND BRAIN
ANTIOXIDANT ACTIVITY OF CARNOSINE, HOMOCARNOSINE, AND ANSERINE PRESENT IN MUSCLE AND BRAIN
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DOI：
10.1073/pnas.85.9.3175
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发表时间：
1988-05-01
影响因子：
11.1
通讯作者：
AMES, BN
中科院分区：
文献类型：
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作者：
KOHEN, R;YAMAMOTO, Y;AMES, BN
肌肽、高肌肽和雁胺在许多动物和人类的肌肉和大脑中都有高浓度的存在。然而，它们的确切功能尚不清楚。通过测试这些化合物在生理浓度下的过氧自由基捕获能力，研究了它们的抗氧化活性。肌肽、同肌肽、鹅氨酸和其他组氨酸衍生物均显示出抗氧化活性。在循环伏安测量中，所有这些具有过氧自由基捕获活性的化合物作为还原剂也具有电化学活性。肌肽还能抑制抗坏血酸和铜离子对脱氧鸟苷的氧化羟基化作用。肌肽的其他作用，如金属离子的螯合，单线态氧的猝灭和氢过氧化物的结合，也进行了讨论。数据表明，这些组氨酸相关化合物在大脑和肌肉中扮演着内源性抗氧化剂的角色。
Carnosine, homocarnosine, and anserine are present in high concentrations in the muscle and brain of many animals and humans. However, their exact function is not clear. The antioxidant activity of these compounds has been examined by testing their peroxyl radical-trapping ability at physiological concentrations. Carnosine, homocarnosine, anserine, and other histidine derivatives all showed antioxidant activity. All of these compounds showing peroxyl radical-trapping activity were also electrochemically active as reducing agents in cyclic voltammetric measurements. Furthermore, carnosine inhibited the oxidative hydroxylation of deoxyguanosine induced by ascorbic acid and copper ions. Other roles of carnosine, such as chelation of metal ions, quenching of singlet oxygen, and binding of hydroperoxides, are also discussed. The data suggest a role for these histidine-related compounds as endogenous antioxidants in brain and muscle.