Effects of caffeine in non-withdrawn volunteers
Effects of caffeine in non-withdrawn volunteers
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DOI：
10.1002/hup.658
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发表时间：
2005-01-01
影响因子：
1.7
通讯作者：
Smith, A
中科院分区：
文献类型：
--
作者：
Christopher, G;Sutherland, D;Smith, A
咖啡因对行为影响的证据在文献中很普遍。它与提高主观警觉性、改善反应时间和增强对新信息的编码有关。然而。关于这些变化是否真的是改善，或者仅仅是对咖啡因戒断的负面影响的逆转，一直存在争论。这项研究使用了每天摄入正常咖啡因量的参与者，减轻了这种潜在的困惑，因为所有参与者在测试时都没有退出。目的确定咖啡因是否会影响非退缩型志愿者的情绪和表现。方法68名志愿者，他们都是经常摄入咖啡因的人，在一天中摄入正常量的咖啡因。然后进行情绪和表现的基线测量，然后双盲给药咖啡因（2毫克/公斤）或安慰剂。在饮用饮料30分钟后再次进行电池测试。结果我们的研究结果与之前的研究相比有了很大的改善。他们的情绪得到了改善，许多认知测试的表现也得到了改善。研究结果讨论了去甲肾上腺素能和胆碱能神经递质系统的关系。结论：这项研究提供了证据，反驳了咖啡因导致的行为改变仅仅是负面戒断效应的逆转。版权所有：John Wiley Sons， Ltd. 2004
Rationale Evidence for the behavioural effects of caffeine is prevalent in the literature. It is associated with increased subjective alertness, improved reaction time and enhanced encoding of new information. However. there is an on-going debate as to whether such changes are in fact improvements or merely a reversal of the negative effects of caffeine withdrawal. Using participants who had consumed their normal daily quota of caffeine this study alleviated this potential confound as all participants were not withdrawn at the time of testing.Objectives To determine whether caffeine influenced the mood and performance of non-withdrawn volunteers.Methods Sixty eight volunteers, all of whom were regular caffeine consumers, consumed their normal amount of caffeine over the course of the day. Baseline measures of mood and performance were then carried out followed by double-blind administration of caffeine (2 mg/kg) or placebo. The test battery was repeated again 30 min after ingestion of the drink.Results Our findings showed improvements comparable to previous research. Mood was improved and performance on a number of cognitive measures was improved. The findings are discussed in relation to both noradrenergic and cholinergic neurotransmitter systems.Conclusions This study provided evidence against the argument that behavioural changes due to caffeine are merely the reversal of negative withdrawal effects. Copyright (C) 2004 John Wiley Sons, Ltd.