Telomere lengths are characteristic in each human individual
Telomere lengths are characteristic in each human individual
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DOI：
10.1016/s0531-5565(01)00218-2
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发表时间：
2002-04-01
影响因子：
3.9
通讯作者：
Nakamura, KI
中科院分区：
文献类型：
--
作者：
Takubo, K;Izumiyama-Shimomura, N;Nakamura, KI
背景。大量的注意力集中在端粒与细胞衰老，不朽和癌症的关系上。然而，端粒和组织更新之间并没有简单的联系。我们最近提出了一个假设，即端粒随着年龄的增长而缩短，不同器官的端粒长度是人类个体的特征。为了验证这一点，研究人员使用从新生儿到百岁老人的大脑皮层、心肌、肝脏、肾脏皮层和脾脏组织中提取的DNA来测量端粒长度。回归分析显示，肝脏、肾皮质和脾脏的端粒减少率为每年29-60个碱基对（bp），但大脑皮质和心肌的端粒减少率未见下降。个体内部组织之间存在显著相关性，如大脑皮质与（vs）心肌、大脑皮质与肝脏、大脑皮质与肾皮质、心肌与肝脏、心肌与肾皮质、肝脏与肾皮质。在大多数情况下，最长的端粒出现在心肌，最短的出现在肝或肾皮层。端粒长度与体内组织更新时间没有明显的相关性，而是个体的特征。(C) 2002爱思唯尔科学有限公司版权所有。
Background. A great deal of attention has been focused on telomeres in relation to cellular aging, immortality, and cancer. However, there is no simple link between telomeres and tissue turnover. We recently proposed a hypothesis that telomere shortening with aging and telomere lengths in different organs are characteristic for human individuals.Methods. To test this, telomere lengths were measured using DNA from cerebral cortex, myocardium, liver, renal cortex and spleen tissues obtained from human subjects ranging in age from neonates to centenarians.Results. Regression analyses demonstrated telomere reduction rates of 29-60 base pair (bp) per year in the liver, renal cortex and spleen, but no such decrease in the cerebral cortex and myocardium. Significant correlation was found between tissues within individuals, such as cerebral cortex versus (vs) myocardium, cerebral cortex vs liver, cerebral cortex vs renal cortex, myocardium vs liver, myocardium vs renal cortex, and liver vs renal cortex. In most cases, the longest telomeres were observed in the myocardium and the shortest in the liver or renal cortex.Conclusions. Telomere lengths did not show clear correlation with tissue renewal times in vivo, but rather were characteristic for individuals. (C) 2002 Elsevier Science Inc. All rights reserved.