Antigen-enabled facile preparation of MOF nanovaccine to activate the complement system for enhanced antigen-mediated immune response
Antigen-enabled facile preparation of MOF nanovaccine to activate the complement system for enhanced antigen-mediated immune response
复制标题
抗原激活的 MOF 纳米疫苗的简便制备，可激活补体系统，增强抗原介导的免疫反应
DOI：
10.1039/c9bm01145e
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发表时间：
2019
影响因子：
6.6
通讯作者：
Huang Yubin
中科院分区：
文献类型：
--
作者：
Qi Yanxin;Wang Lei;Guo Huanhuan;Pan Yong;Xie Zhigang;Jin Ningyi;Huang Yubin
由于目前的亚单位疫苗受到体内半衰期短和在没有佐剂的情况下单独使用时免疫应答弱的限制，因此存在对将载体与补体激活信号组合以实时中断爆发的未满足的需求。氨基功能化锆基MOFs（UiO-AM）可以激活补体系统，在天然免疫和获得性免疫中发挥重要作用。我们的数据提供了设计原则，研究补体激活作为一种安全的疫苗载体，可以有效地提高免疫反应的抗原在体内。
Since current subunit vaccines are limited by a short half-life in vivo and weak immune responses when used alone without adjuvants, there is an unmet need for combing carriers with complement activation signals to interrupt outbreaks in real-time. Amino-functionalized zirconium-based MOFs (UiO-AM) could activate the complement system, which plays an important role in innate and adaptive immunity. Our data provide design principles for studies on complement activation as a safe vaccine carrier that can effectively enhance immune responses against antigens in vivo.