Androgen and estrogen signaling at the cell membrane via G-proteins and cyclic adenosine monophosphate
Androgen and estrogen signaling at the cell membrane via G-proteins and cyclic adenosine monophosphate
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DOI：
10.1016/s0039-128x(98)00108-1
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发表时间：
1999-01-01
期刊：
影响因子：
2.7
通讯作者：
Romas, NA
中科院分区：
文献类型：
--
作者：
Rosner, W;Hryb, DJ;Romas, NA
公知雄激素和雌激素通过与特异性细胞内受体结合来启动其作用。类固醇-受体相互作用、受体和这些类固醇与其各自受体的结合所导致的转录激活的细节已经并将继续被深入研究。最近，越来越明显的是，类固醇可能通过这种经典途径以外的途径与细胞相互作用。这种交流将涉及性激素对信号转导途径的激活，该信号转导途径起源于细胞膜并利用环磷酸腺苷（cAMP）作为第二信使。该系统由三种成分组成，激动剂类固醇，性激素结合球蛋白（SHBG）和SHBG的膜受体（R-SHBG）。SHBG是一种具有良好特征的血浆蛋白，具有两个结合位点，一个结合某些雌激素和雄激素，另一个结合R-SHBG。这一新的信号转导系统的特点，从SHBG与R-SHBG的相互作用，G蛋白的中介作用，cAMP的产生，第二信使的下游效应将进行审查。(C)1999 Elsevier Science Inc. All rights reserved.
Androgens and estrogens are well-known to initiate their actions by binding to specific intracellular receptors. The steroid-receptor interaction, the receptors, and the details of transcriptional activation consequent to the binding of these steroids with their respective receptors have been, and continue to be, intensively studied. More recently, it has become increasingly apparent that steroids may interact with cells by other than this classic pathway. This communication will deal with activation by sex hormones of a signal transduction pathway that originates at the cell membrane and utilizes cyclic adenosine monophosphate (cAMP) as a second messenger. The system consists of three components, an agonist steroid, sex hormone-binding globulin (SHBG), and a membrane receptor (R-SHBG) for SHBG. SHBG is a well-characterized plasma protein that has two binding sites, one binds certain estrogens and androgens, and the other binds to R-SHBG. The characteristics of this novel signal transduction system, from the interaction of SHBG with R-SHBG, to the intermediacy of G-proteins, to cAMP generation, to downstream effects of the second messenger will be reviewed. (C) 1999 Elsevier Science Inc. All rights reserved.