Prognostic Significance of Preoperative Urine Cytology in Low-grade Non-muscle-invasive Bladder Cancer.
Prognostic Significance of Preoperative Urine Cytology in Low-grade Non-muscle-invasive Bladder Cancer.
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发表时间：
2016-02
影响因子：
2
通讯作者：
K. Kiyoshima;Masakazu Akitake;M. Shiota;A. Takeuchi;R. Takahashi;J. Inokuchi;K. Tatsugami;A. Yokomizo;M. Eto
中科院分区：
文献类型：
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作者：
K. Kiyoshima;Masakazu Akitake;M. Shiota;A. Takeuchi;R. Takahashi;J. Inokuchi;K. Tatsugami;A. Yokomizo;M. Eto
目的探讨术前尿细胞学检查对低度恶性膀胱癌的临床意义。患者和方法我们回顾性调查了2000年1月至2014年9月期间诊断为原发性低级别（Ta）膀胱尿路上皮癌的155例患者的记录。结果与细胞学分级为II级或更低的患者相比，细胞学分级为III级或更高的患者具有更高的分级（G2）（p=0.01）、更大的肿瘤（≥15 mm，p=0.0009）和更短的无复发生存期（p<0.0001）。然而，无复发生存期的考克斯比例风险分析仅确定了肿瘤大小（≥15 mm）（危害比=5.97，95%可信区间=2.39-17.29; p<0.0001）作为预后不良的预测因子，尽管术前细胞学分级为III级或更高的患者显示出膀胱内复发频繁的趋势（风险比=1.98，95%置信区间=0.96-4.2; p=0.063）。结论术前尿脱落细胞学检查和肿瘤大小是预测膀胱癌术后复发的有效指标。
AIM To examine the clinical significance of preoperative urine cytology in patients with low-grade bladder cancer. PATIENTS AND METHODS We retrospectively investigated the records of 155 patients diagnosed with primary low-grade (Ta) urothelial carcinoma of the bladder between January 2000 and September 2014. RESULTS Patients with class III or greater cytology had significantly higher-grade (G2) (p=0.01), larger tumors (≥15 mm, p=0.0009) and significantly shorter recurrence-free survival compared to patients with class II or lower cytology (p<0.0001). However, Cox proportional hazards analysis for recurrence-free survival only identified tumor size (≥15 mm) (hazard ratio=5.97, 95% confidence interval=2.39-17.29; p<0.0001) as a predictor of poor prognosis, although patients with class III or higher preoperative cytology showed a tendency towards frequent intravesical recurrence (hazard ratio=1.98, 95% confidence interval=0.96-4.2; p=0.063). CONCLUSION Preoperative urine cytology, in addition to tumor size, might be a useful predictor of intravesical recurrence of bladder cancer.