A Randomized Controlled Trial of an Outpatient Protocol for Transitioning Children from Tube to Oral Feeding: No Need for Amitriptyline.
A Randomized Controlled Trial of an Outpatient Protocol for Transitioning Children from Tube to Oral Feeding: No Need for Amitriptyline.
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DOI：
10.1016/j.jpeds.2016.02.013
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Hyman PE
中科院分区：
文献类型：
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作者：
Davis AM;Dean K;Mousa H;Edwards S;Cocjin J;Almadhoun O;He J;Bruce A;Hyman PE
评估阿米替林在门诊方案中对医学复杂儿童从管饲转为口服喂养的有效性。在四个站点的多学科门诊喂养团队中看到的21名儿童被招募到一项为期六个月的门诊治疗方案的随机安慰剂对照试验中，该方案包括行为，口腔运动，营养和药物成分。所有完成六个月计划的儿童（73%）断奶后只接受口服喂养，无论小组分配如何。从管饲到口服喂养的转变导致BMI百分位数和疼痛的降低，生活质量的一些改善，并且成本没有统计学显著变化。阿米替林不是这个有效的门诊、跨学科方案的关键组成部分，用于使儿童从管饲断奶到口服喂养。临床试验注册Trials.gov：NCT 01206478
To assess the role of amitriptyline in the effectiveness of an outpatient protocol for weaning medically complicated children from tube to oral feeding. Twenty-one children seen in multidisciplinary outpatient feeding teams across four sites were recruited to a randomized placebo-controlled trial of a six-month outpatient treatment protocol with behavioral, oral-motor, nutrition and medication components. All of the children who completed the six-month program (73%) were weaned to receive only oral feeding, regardless of group assignment. The transition from tube to oral feeding resulted in decreases in BMI percentile and pain, some improvements in quality of life, and no statistically significant changes in cost. Amitriptyline is not a key component of this otherwise effective outpatient, interdisciplinary protocol for weaning children from tube to oral feeding. Trial registration Clinical Trials.gov: NCT01206478