The potential role of Wolbachia in controlling the transmission of emerging human arboviral infections.
The potential role of Wolbachia in controlling the transmission of emerging human arboviral infections.
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DOI：
10.1097/qco.0000000000000342
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发表时间：
2017-02
影响因子：
3.9
通讯作者：
Solomon T
中科院分区：
文献类型：
--
作者：
Kamtchum-Tatuene J;Makepeace BL;Benjamin L;Baylis M;Solomon T
沃尔巴克氏体是一种革兰氏阴性细胞内细菌，天然存在于超过一半的节肢动物物种中。这些细菌不仅可以降低节肢动物媒介的适合度和繁殖能力，而且还可以提高它们对节肢动物传播病毒（虫媒病毒）的抵抗力。本文综述了支持以沃尔巴克氏体为基础的控制登革热和其他虫媒病毒感染传播策略的证据。在澳大利亚现场释放受沃尔巴克氏体感染的蚊子1年后进行的研究表明，登革热病毒（DENV）在蚊子中的复制和传播受到抑制。最近的数学模型表明，这种策略可以减少70%的DENV传播。因此，世卫组织鼓励各国加强针对其他虫媒病毒感染的基于沃尔巴克氏体的预防战略的制定和实施。然而，关于沃尔巴克氏体预防其他虫媒病毒感染传播的有效性的证据仍然限于实验框架，在某些情况下结果相互矛盾。有必要在各种气候条件下证明这些策略在实地的有效性，选择具有最佳病原体干扰/传播权衡的沃尔巴克氏体菌株，并继续建立社区接受度。沃尔巴克氏体代表了一个有前途的工具，用于控制虫媒病毒感染的传播，需要进一步开发。需要进行长期环境监测，以便及时发现沃尔巴克氏体/病媒/病毒相互作用的潜在变化。
Wolbachia is a genus of Gram-negative intracellular bacteria that is naturally found in more than half of all arthropod species. These bacteria cannot only reduce the fitness and the reproductive capacities of arthropod vectors, but also increase their resistance to arthropod-borne viruses (arboviruses). This article reviews the evidence supporting a Wolbachia-based strategy for controlling the transmission of dengue and other arboviral infections. Studies conducted 1 year after the field release of Wolbachia-infected mosquitoes in Australia have demonstrated the suppression of dengue virus (DENV) replication in and dissemination by mosquitoes. Recent mathematical models show that this strategy could reduce the transmission of DENV by 70%. Consequently, the WHO is encouraging countries to boost the development and implementation of Wolbachia-based prevention strategies against other arboviral infections. However, the evidence regarding the efficacy of Wolbachia to prevent the transmission of other arboviral infections is still limited to an experimental framework with conflicting results in some cases. There is a need to demonstrate the efficacy of such strategies in the field under various climatic conditions, to select the Wolbachia strain that has the best pathogen interference/spread trade-off, and to continue to build community acceptance. Wolbachia represents a promising tool for controlling the transmission of arboviral infections that needs to be developed further. Long-term environmental monitoring will be necessary for timely detection of potential changes in Wolbachia/vector/virus interactions.