Curcumin-mediated lifespan extension in Caenorhabditis elegans
Curcumin-mediated lifespan extension in Caenorhabditis elegans
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DOI：
10.1016/j.mad.2011.07.008
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发表时间：
2011-10-01
影响因子：
5.3
通讯作者：
Wang, Teng-Ting
中科院分区：
文献类型：
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作者：
Liao, Vivian Hsiu-Chuan;Yu, Chan-Wei;Wang, Teng-Ting
姜黄素是草药和膳食香料姜黄（Curcuma longa）中的活性成分。它具有广泛的生物活性，包括抗炎、抗氧化、化学预防和化学治疗活性。我们研究了姜黄素对秀丽隐杆线虫的寿命和衰老的影响，发现姜黄素在衰老过程中具有增加寿命和减少细胞内活性氧和脂褐素的作用。我们分析了可能影响姜黄素延长寿命的因素。我们发现姜黄素能延长C.秀丽隐杆线虫是由于其抗氧化特性，而不是其抗微生物特性。此外，我们发现寿命延长对身体大小和咽泵率有影响，但对繁殖没有影响。最后，对选定的应激和寿命相关突变株的寿命测试显示，延长寿命的表型不存在于osr-1、sek-1、mek-1、skn-1、unc-43、sir-2.1和age-1突变株中，而姜黄素处理延长了mev-1和daf-16突变株的寿命。我们的研究揭示了姜黄素暴露在体内对长寿和衰老的多种作用模式和信号通路。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Curcumin is the active ingredient in the herbal medicine and dietary spice, turmeric (Curcuma longa). It has a wide range of biological activities, including anti-inflammatory, antioxidant, chemopreventive, and chemotherapeutic activities. We examined the effects of curcumin on the lifespan and aging in Caenorhabditis elegans, and found that it responded to curcumin with an increased lifespan and reduced intracellular reactive oxygen species and lipofuscin during aging. We analyzed factors that might influence lifespan extension by curcumin. We showed that lifespan extension by curcumin in C. elegans is attributed to its antioxidative properties but not its antimicrobial properties. Moreover, we showed that lifespan extension had effects on body size and the pharyngeal pumping rate but not on reproduction. Finally, lifespan tests with selected stress- and lifespan-relevant mutant strains revealed that the lifespan-extending phenotype was absent from the osr-1, sek-1, mek-1, skn-1, unc-43, sir-2.1, and age-1 mutants, whereas curcumin treatment prolonged the lifespan of mev-1 and daf-16 mutants. Our study has unraveled a diversity of modes of action and signaling pathways to longevity and aging with curcumin exposure in vivo. (C) 2011 Elsevier Ireland Ltd. All rights reserved.