Paternal dioxin, preterm birth, intrauterine growth retardation, and infant death
Paternal dioxin, preterm birth, intrauterine growth retardation, and infant death
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DOI：
10.1097/00001648-199803000-00010
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发表时间：
1998-03-01
期刊：
影响因子：
5.4
通讯作者：
Boyle, CA
中科院分区：
文献类型：
--
作者：
Michalek, JE;Rahe, AJ;Boyle, CA
我们研究了越南战争期间负责喷洒除草剂的“牧场之手行动”退伍军人的父亲接触橙剂及其二恶英污染物（2,3,7,8 四氯二苯并-对二恶英）和早产、宫内发育迟缓或婴儿死亡的情况。对照组包括同一时期在东南亚服役且未因职业接触除草剂的空军退伍军人。我们研究了父亲在东南亚服役期间或之后怀上的孩子，并根据 1987 年或 1992 年测量的父亲二恶英暴露情况推断到孩子受孕的时间。我们将每个孩子分配到四个暴露类别之一：比较和三个牧场手类别（背景、低、高）。高（相对风险 = 1.3）和背景（相对风险 = 1.4）类别的儿童早产风险较高。在任何暴露类别中，宫内生长迟缓的风险均未增加。所有 Ranch Hand 儿童的婴儿死亡风险均有所增加，其中高（相对风险 = 4.5）和背景（相对风险 = 3.2）类别的增幅最大。这些模式表明，早产和婴儿死亡相对风险的增加可能与父亲的二恶英水平无关。
We studied paternal exposure to Agent Orange and its dioxin contaminant (2,3,7,8 tetrachlorodibenzo-p-dioxin) and preterm birth, intrauterine growth retardation, or infant death in veterans of Operation Ranch Hand, the unit responsible for spraying herbicides during the Vietnam war. A Comparison group of Air Force veterans who served in Southeast Asia during the same time period and who were not occupationally exposed to herbicides was included. We studied children conceived during or after the father's service in Southeast Asia and based exposure on paternal dioxin measured in 1987 or 1992 extrapolated to the time of conception of the child. We assigned each child to one of four exposure categories: Comparison and three Ranch Hand categories (Background, Low, High). Children in the High (relative risk = 1.3) and Background (relative risk = 1.4) categories were at increased risk of preterm birth. The risk of intrauterine growth retardation was not increased in any exposure category. The risk of infant death was increased in all Ranch Hand children, with the greatest increases in the High (relative risk = 4.5) and Background (relative risk = 3.2) categories. These patterns indicate that the increases in the relative risk of preterm birth and infant death may not be related to paternal dioxin level.