Impairment of repetitive impulse conduction in experimentally demyelinated and pressure-injured nerves 12
Impairment of repetitive impulse conduction in experimentally demyelinated and pressure-injured nerves 12
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实验性脱髓鞘和压力损伤神经的重复脉冲传导受损 12
DOI：
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发表时间：
1972
影响因子：
11
通讯作者：
F. A. Davis
中科院分区：
文献类型：
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作者：
F. A. Davis
在实验性变态反应性神经炎（EAN）豚鼠的节段性脱髓鞘周围神经和压力损伤的青蛙坐骨神经中研究了重复脉冲传导。保持在37°C下的正常豚鼠坐骨腓神经在高达200/sec的刺激频率下传导复合动作电位，仅轻微幅度降低。相比之下，维持在37°C的EAN豚鼠神经在以10-25/秒的速度缓慢刺激时，动作电位振幅会迅速进行性降低。刺激频率越高，下降越大。在100次刺激/秒时，所有EAN制剂显示动作电位振幅降低超过50%。这些影响是可逆的。在压力损伤的青蛙坐骨神经中，在低至50/秒的刺激频率下也发生了类似的效应。正常的青蛙神经进行高达200脉冲/秒，几乎没有幅度下降。本文对这些结果的可能机制和临床意义进行了讨论。
Repetitive impulse conduction was studied in segmentally demyelinated peripheral nerves in guinea-pigs with experimental allergic neuritis (EAN) and in pressure-injured frog sciatic nerves. Normal guinea-pig sciatic-peroneal nerves maintained at 37°C conducted compound action potentials with only minor amplitude decreases at stimulus frequencies up to 200/sec. In contrast, nerves in EAN guinea-pigs maintained at 37°C demonstrated a rapidly progressive decrease in action potential amplitude when stimulated as slowly as 10-25/sec. The decrease is greater the higher the frequency of stimulation. At 100 stimuli/sec all EAN preparations showed more than a 50% reduction in action potential amplitude. These effects are reversible. In pressure-injured frog sciatic nerves similar effects occurred at stimulus frequencies as low as 50/sec. Normal frog nerves conducted up to 200 impulses/sec with little amplitude decrease. The probable mechanism and clinical significance of these results are discussed.