Methylphenidate decreases regional cerebral blood flow in normal human subjects.
Methylphenidate decreases regional cerebral blood flow in normal human subjects.
复制标题
哌醋甲酯会降低正常人的局部脑血流量。
DOI：
10.1016/0024-3205(94)00873-6
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发表时间：
1994
期刊：
影响因子：
6.1
通讯作者：
Warner,D
中科院分区：
文献类型：
--
作者：
Wang,GJ;Volkow,ND;Fowler,JS;Ferrieri,R;Schlyer,DJ;Alexoff,D;Pappas,N;Lieberman,J;King,P;Warner,D
为探讨哌醋甲酯（MP）对脑血流量的影响，对5名健康男性静脉注射MP（0.5mg/kg）前后进行了~（15）O-水和正电子发射断层扫描（PET）研究。MP在给药后5-10分钟（25±11%）和30分钟（20±10%）显著降低全脑CBF。CBF的下降在整个大脑中是均匀的（区域性下降23-30%），可能反映了MP的血管活性。当长期开具本品处方和/或给予脑血管损害受试者时，应考虑MP的血管活性。
To assess the effects of methylphenidate (MP) on cerebral blood flow (CBF), 5 healthy males were studied using15O-water and positron emission tomography before and after MP (0.5mg/kg iv). MP significantly decreased whole brain CBF at 5–10 minutes (25±11%) and at 30 minutes (20±10%) after its administration. Decrements in CBF were homogeneous throughout the brain (regional decrements 23–30%) and probably reflect the vasoactive properties of MP. The vasoactive properties of MP should be considered when prescribing this drug chronically and/or when giving it to subjects with cerebrovascular compromise.