Oblongolides from the Endophytic Fungus Phomopsis sp BCC 9789
Oblongolides from the Endophytic Fungus Phomopsis sp BCC 9789
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DOI：
10.1021/np900650c
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发表时间：
2010-01-01
影响因子：
5.1
通讯作者：
Lumyong, Saisaimorn
中科院分区：
文献类型：
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作者：
Bunyapaiboonsri, Taridaporn;Yoiprommarat, Seangaroon;Lumyong, Saisaimorn
从内生真菌拟茎点霉（Phomopsis sp. BCC 9789）中分离得到6个新的长圆内酯化合物：W1，W2，X，Y，Z（1-3，6，7）和2-脱氧-4 α-羟基长圆内酯X（4），以及已知化合物长圆内酯（8），长圆内酯T，C，Q（5，9，10）和（-）-5-甲基mellein。化合物7显示抗HSV-1活性（IC（50）= 14 μ M）和对KB、BC、NCI-H187和非恶性（Vero）细胞系的细胞毒活性，IC（50）值分别为37、26、32和60 μ M。还观察到化合物6对BC细胞系的细胞毒性活性，所有IC（50）值均为48 μ M。
Six new oblongolides, W1, W2, X, Y, and Z (1-3, 6, 7) and 2-deoxy-4 alpha-hydroxyoblongolide X (4), and the known compounds oblongolide (8), oblongolides T, C, and Q (5, 9, 10), and (-)-5-methylmellein were isolated from the endophytic fungus Phomopsis sp. BCC 9789. Compound 7 showed anti-HSV-1 activity (IC(50) = 14 mu M) and cytotoxic activities against KB, BC, NCI-H187, and nonmalignant (Vero) cell lines with respective IC(50) values of 37, 26, 32, and 60 mu M. Cytotoxic activity against the BC cell line was also observed for compound 6, with all IC(50) value of 48 mu M.