Molecular regulation of androgen action in prostate cancer
Molecular regulation of androgen action in prostate cancer
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DOI：
10.1002/jcb.20794
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发表时间：
2006-10-01
影响因子：
4
通讯作者：
Tindall, Donald J.
中科院分区：
文献类型：
--
作者：
Dehm, Scott M.;Tindall, Donald J.
雄激素是前列腺分化和功能的关键调节剂，以及前列腺癌的生长和生存。因此，雄激素消融是用于传播前列腺癌的首选全身治疗。雄激素作用通过结合雄激素受体（AR）（核受体转录因子）在靶组织中施加。从历史上看，AR介导的基因表达程序知之甚少。然而，最近的基因表达分析和更传统的单基因表征研究表明，许多雄激素调节的基因是正常和恶性前列腺组织中雄激素作用的重要介体。这篇综述将重点放在雄激素调节的基因表达程序上，并检查最近确定的雄激素调节的基因可能有助于前列腺癌的发展和进展。我们还将总结一些最近的研究，这些研究试图揭示这些基因在独立的前列腺癌中如何解除这些基因的管制。
Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor. Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This review will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. We will also summarize several recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer.