One-Pot Catalytic Synthesis of α-Tetrasubstituted Amino Acid Derivatives via In Situ Generation of N-Unsubstituted Ketimines
One-Pot Catalytic Synthesis of α-Tetrasubstituted Amino Acid Derivatives via In Situ Generation of N-Unsubstituted Ketimines
复制标题
原位生成 N-未取代酮亚胺一锅催化合成 α-四取代氨基酸衍生物
DOI：
10.1021/acs.orglett.2c02587
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发表时间：
2022
期刊：
影响因子：
5.2
通讯作者：
T.
中科院分区：
文献类型：
--
作者：
Kondo;Y.; Hirazawa;Y.; Kadota;T.; Yamada;K.; Morisaki;K.; Morimoto;H.;* Ohshima;T.
报道了原位生成n -未取代氯胺酮一锅催化合成α-四取代氨基酸衍生物的方法。由于n -未取代酮胺的不可逆生成，收率高于常规一锅反应条件下的收率。这种方法避免了用烷基取代基分离不稳定的未取代的酮胺，简化了高度密集的α-氨基酸衍生物的合成。
A one-pot catalytic synthesis of α-tetrasubstituted amino acid derivatives via in situ generation ofN-unsubstituted ketimines is reported. Because of the irreversible formation ofN-unsubstituted ketimines, the yields were higher than those generated under the conventional one-pot reaction conditions. This process prevents the need to isolate unstableN-unsubstituted ketimines with alkyl substituents and streamlines the synthesis of highly congested α-amino acid derivatives.