Global arginine bioavailability ratio is decreased in patients with major depressive disorder
Global arginine bioavailability ratio is decreased in patients with major depressive disorder
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DOI：
10.1016/j.jad.2017.12.030
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发表时间：
2018-03-15
影响因子：
6.6
通讯作者：
Lehto, Soili M.
中科院分区：
文献类型：
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作者：
Ali-Sisto, Toni;Tolmunen, Tommi;Lehto, Soili M.
背景：重性抑郁障碍（MDD）的特征是氧化应激和亚硝化应激增加。我们比较了一氧化氮代谢，方法：对99例抑郁症患者和253例非抑郁症对照者进行问卷调查，分析其精氨酸生物利用度（GABR）及相关血清氨基酸的变化。采用超高效液相色谱-质谱联用分析空腹血清样本，以测定血清中鸟氨酸、精氨酸、瓜氨酸以及对称和不对称二甲基精氨酸的水平。GABR计算为精氨酸除以鸟氨酸加瓜氨酸的总和。我们比较了以下三组之间的上述指标：1）MDD患者和对照组，2）缓解（n= 33）和非缓解（n = 45）MDD患者，3）缓解组和非缓解组的基线和随访。在调整潜在混杂因素后，较低的精氨酸水平（OR 0.98，95% CI 0.97-0.99）和较低的GABR（OR 0.13，95% CI 0.03-0.50）与MDD组相比与非抑郁组相关。与组内基线值相比，随访后缓解组的GABR、精氨酸和对称二甲基精氨酸降低，鸟氨酸升高。未缓解组显示精氨酸和鸟氨酸水平升高，GABR降低。缓解和非缓解groups.Limitations之间没有显着差异记录：MDD组是不是medication-free.Conclusions：精氨酸的生物利用度可能会降低MDD。这可能会损害一氧化氮的产生，从而增加中枢神经系统的氧化应激。
Background: Major depressive disorder (MDD) is characterized by increased oxidative and nitrosative stress. We compared nitric oxide metabolism, i.e., the global arginine bioavailability ratio (GABR) and related serum amino acids, between MDD patients and non-depressed controls, and between remitted and non-remitted MDD patients.Methods: Ninety-nine MDD patients and 253 non-depressed controls, aged 20-71 years, provided background data via questionnaires. Fasting serum samples were analyzed using ultra-performance liquid chromatography coupled to mass spectrometry to determine the serum levels of ornithine, arginine, citrulline, and symmetric and asymmetric dimethylarginine. GABR was calculated as arginine divided by the sum of ornithine plus citrulline. We compared the above measures between: 1) MDD patients and controls, 2) remitted (n= 33) and non-remitted (n = 45) MDD patients, and 3) baseline and follow-up within the remitted and non-remitted groups.Results: Lower arginine levels (OR 0.98, 95% CI 0.97-0.99) and lower GABR (OR 0.13, 95% CI 0.03-0.50) were associated with the MDD vs. the non-depressed group after adjustments for potential confounders. The remitted group showed a decrease in GABR, arginine, and symmetric dimethylarginine, and an increase in ornithine after the follow-up compared with within-group baseline values. The non-remitted group displayed an increase in arginine and ornithine levels and a decrease in GABR. No significant differences were recorded between the remitted and non-remitted groups.Limitations: The MDD group was not medication-free.Conclusions: Arginine bioavailability may be decreased in MDD. This could impair the production of nitric oxide, and thus add to oxidative stress in the central nervous system.