Extracellular vesicles in the tumor immune microenvironment
Extracellular vesicles in the tumor immune microenvironment
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肿瘤免疫微环境中的细胞外囊泡
DOI：
10.1016/j.canlet.2021.05.032
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发表时间：
2021-06-03
期刊：
影响因子：
9.7
通讯作者：
Chen, Hang-zi
中科院分区：
文献类型：
--
作者：
Hou, Pei-pei;Chen, Hang-zi
细胞外囊泡（extracellular vesicles，EVs）作为细胞间通讯的主要介质，参与了多种重要的生理和病理过程，近年来受到广泛关注。它们由几乎所有的细胞类型分泌，并携带生物活性物质，如蛋白质、脂质和核酸，这些物质可以从宿主细胞传递到受体细胞，从而引起受体细胞的表型和功能改变。最近的证据表明，EV在重塑肿瘤免疫微环境（TIME）中起着至关重要的作用。来源于肿瘤细胞和免疫细胞的EV介导近端和远端位点的相互通信，这决定了肿瘤的命运和抗肿瘤治疗效果。本文综述了目前对EV及其在TIME重塑和调节肿瘤特异性免疫中的作用的认识。我们主要讨论了肿瘤细胞和肿瘤浸润免疫细胞之间的相互调节，通过在时间的EV的交付。我们还描述了目前研究的局限性，并讨论了进一步研究的方向。
Extracellular vesicles (EVs) have gained significant attention in recent decades as major mediators of intercellular communication that are involved in various essential physiological and pathological processes. They are secreted by almost all cell types and carry bioactive materials, such as proteins, lipids and nucleic acids, that can be transmitted from host cells to recipient cells, thereby eliciting phenotypic and functional alterations in the recipient cells. Recent evidence shows that EVs play essential roles in remodeling the tumor immune microenvironment (TIME). EVs derived from tumor cells and immune cells mediate mutual communication at proximal and distal sites, which determines tumor fate and antitumor therapeutic effectiveness. In this review, the current understanding of EVs and their roles in remodeling the TIME and modulating tumor-specific immunity are summarized. We mainly discuss the mutual regulation between tumor cells and tumor-infiltrating immune cells through the delivery of EVs in the TIME. We also describe the limitations of current studies and discuss directions for further research.