Endothelial cell apoptosis in sepsis
Endothelial cell apoptosis in sepsis
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DOI：
10.1097/00003246-200205001-00009
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发表时间：
2002-05-01
影响因子：
8.8
通讯作者：
Karl, IE
中科院分区：
文献类型：
--
作者：
Hotchkiss, RS;Tinsley, KW;Karl, IE
目的：探讨内皮细胞凋亡在脓毒症发病机制中的潜在作用。数据来源：发表在生物医学期刊上的研究和作者实验室的研究。研究选择：内毒素和脓毒症模型中内皮细胞凋亡的体外和体内研究。数据提取和合成：介绍了研究细胞凋亡在内毒素血症和脓毒症中作用的相关研究。不同的研究和差异的结果的潜在原因的分歧的结果。细胞凋亡在脓毒症中的重要性以及对内皮细胞和器官功能的潜在影响被强调。细胞凋亡是脓毒症时淋巴细胞和胃肠道上皮细胞死亡的重要机制。尽管大量的体外研究表明内皮细胞凋亡可以响应于某些病原生物体（例如，立克次氏体），缺乏在体内脓毒症模型中记录内皮细胞凋亡的数据。由于经历细胞凋亡的内皮细胞从血管基底膜分离，进入循环，并被快速清除，因此可能难以在脓毒症的体内模型中检测内皮细胞凋亡。脓毒症中内皮细胞凋亡的影响可能对宿主存活有害或有益，这取决于特定的病原体。
Objective: To discuss a potential role for endothelial cell apoptosis in the pathogenesis of sepsis.Data Sources: Studies published in biomedical journals and studies from the authors' laboratory. Study selection: In vitro and in vivo studies of endothelial cell apoptosis in endotoxin and sepsis models.Data Extraction and Synthesis: Relevant studies that investigate the role of apoptosis in endotoxemia and sepsis are presented. The divergent results of the different studies and the potential reasons for the discrepant findings are presented. The importance of apoptosis in sepsis and the potential impact on endothelial cells and organ function are highlighted.Conclusions. Apoptosis is an important mechanism of lymphocyte and gastrointestinal epithelial cell death in sepsis. Although abundant in vitro studies indicate that endothelial cell apoptosis can occur in response to certain pathogenic organisms (e.g., Rickettsia rickettsii), data documenting endothelial cell apoptosis in in vivo models of sepsis are lacking. Because endothelial cells that undergo apoptosis detach from the vessel basement membrane, enter the circulation, and are rapidly cleared, it may be difficult to detect endothelial cell apoptosis in in vivo models of sepsis. The impact of endothelial cell apoptosis in sepsis may either be detrimental or beneficial to host survival, depending on the particular pathogen.