Bilateral periocular actinic granuloma in a patient with renal failure: a clinicopathologic study.
Bilateral periocular actinic granuloma in a patient with renal failure: a clinicopathologic study.
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肾功能衰竭患者的双侧眼周光化性肉芽肿：临床病理学研究。
DOI：
10.1007/s004170050136
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Grossniklaus,HE
中科院分区：
文献类型：
--
作者：
Spraul,CW;Wojno,T;Grossniklaus,HE
·目的：我们报告一名患有终末期肾病的50岁男性，出现双侧内眦和外眦结节。方法：将结节切除，10%福尔马林和2.5%戊二醛固定，分别进行光镜和电镜检查。 肉芽肿反应以弹力纤维为中心，纤维周围有巨细胞吞噬。确定了营养不良性钙化区域。诊断为光化性肉芽肿。鉴别诊断和组织病理学的光化性肉芽肿，即环状肉芽肿，类风湿性结节，坏死性黄色肉芽肿，进行了讨论。结论：这种情况下的光化性肉芽肿起源于太阳受损的眼周皮肤提供了进一步的证据，弹性变性可能与巨细胞反应。 然而，目前尚不清楚哪些抗原负责启动肉芽肿反应，以及弹性组织变性材料本身是否能引起肉芽肿反应。
· Purpose: We report a 50-year-old man with end-stage renal disease who has developed bilateral inner and outer canthal nodules. · Methods: The nodules were excised, fixed in 10% formalin and 2.5% glutaraldehyde, and processed for light and electron microscopy, respectively. · Results: Histological examination showed elastotic changes with associated granulomatous inflammation. The granulomatous reaction was centered around elastotic fibers, and some giant cells engulfed the fibers. Areas of dystrophic calcification were identified. A diagnosis of actinic granuloma was made. The differential diagnosis and histopathology of actinic granuloma, i.e. granuloma annulare, rheumatoid nodule, and necrobiotic xanthogranuloma, are discussed. · Conclusion: This case of an actinic granuloma originating in the sun-damaged periocular skin provides further evidence that elastotic degeneration may be associated with a giant cell reaction. It is, however, unclear which antigens are responsible for initiating the granulomatous response and whether elastotic material on its own can elicit a granulomatous reaction.