MECHANICAL RELAXATION OF THE HAIR BUNDLE MEDIATES ADAPTATION IN MECHANOELECTRICAL TRANSDUCTION BY THE BULLFROGS SACCULAR HAIR CELL
MECHANICAL RELAXATION OF THE HAIR BUNDLE MEDIATES ADAPTATION IN MECHANOELECTRICAL TRANSDUCTION BY THE BULLFROGS SACCULAR HAIR CELL
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DOI：
10.1073/pnas.84.9.3064
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发表时间：
1987-05-01
影响因子：
11.1
通讯作者：
HUDSPETH, AJ
中科院分区：
文献类型：
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作者：
HOWARD, J;HUDSPETH, AJ
青蛙内耳毛细胞的机电转导表现出适应性：对毛束持续偏转的电响应在数十毫秒的时间内下降。我们通过测量施加力刺激后发束刚度的变化来研究力学在适应中的作用。在用玻璃纤维进行阶梯刺激后，囊状毛细胞的毛束最初具有.apprxeq的硬度。 1 mN .cntdot。 m-1。然后刚度下降到接近 0.6 mN .cntdot 的稳态水平。 m-1 的时间过程与受体电流的适应时间过程相当。发束可以被建模为弹簧和串联弹簧和缓冲器的并联组合，弹簧代表静纤毛的旋转刚度，串联弹簧和缓冲器分别代表负责通道门控的弹性元件和适应装置。
Mechanoelectrical transduction by hair cells of the frog''s internal ear displays adaptation: the electrical response to a maintained deflection of the hair bundle declines over a period of tens of milliseconds. We investigated the role of mechanics in adaptation by measuring changes in hair-bundle stiffness following the application of force stimuli. Following step stimulation with a glass fiber, the hair bundle of a saccular hair cell intially had a stiffness of .apprxeq. 1 mN .cntdot. m-1. The stiffness then declined to a steady-state level near 0.6 mN .cntdot. m-1 with a time course comparable to that of adaptation in the receptor current. The hair bundle may be modeled as the parallel combination of a spring, which represents the rotational stiffness of the stereocilia, and a series spring and dashpot, which respectively, represent the elastic element responsible for channel gating and the apparatus for adaptation.