Dehydroepiandrosterone and 16 alpha-bromo-epiandrosterone: inhibitors of Epstein-Barr virus-induced transformation of human lymphocytes.
Dehydroepiandrosterone and 16 alpha-bromo-epiandrosterone: inhibitors of Epstein-Barr virus-induced transformation of human lymphocytes.
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脱氢表雄酮和 16 α-溴-表雄酮：EB 病毒诱导的人类淋巴细胞转化的抑制剂。
DOI：
10.1093/carcin/2.7.683
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发表时间：
1981
期刊：
影响因子：
4.7
通讯作者：
Swern,D
中科院分区：
文献类型：
--
作者：
Henderson,E;Schwartz,A;Pashko,L;Abou-Gharbia,M;Swern,D
脱氢表雄酮（DHEA）是一种主要的肾上腺分泌产物，是哺乳动物葡萄糖-6-磷酸脱氢酶（G6PDH）的有效抑制剂。长期使用这种类固醇治疗可以抑制C3H小鼠自发性乳腺癌的发展。DHEA现在被证明可以抑制eb病毒（EBV）诱导的人类淋巴细胞的形态转化和DNA合成的刺激。16α- br -表雄酮是DHEA类似物，作为G6PDH抑制剂的效力是DHEA的60倍，作为ebv诱导转化的抑制剂要有效得多。
Dehydroepiandrosterone (DHEA), a major adrenal secretory product in men and women, is a potent inhibitor of mammalian glucose-6-phosphate dehydro-genase (G6PDH). Long-term treatment with this steroid has previously been found to suppress spontaneous breast cancer development in C3H mice. DHEA is now shown to inhibit Epstein-Barr virus (EBV)-induced morphologic transformation and stimulation of DNA synthesis in human lymphocytes. 16α-Br-epiandrosterone, a DHEA analog that is about 60 times as potent as DHEA as an inhibitor of G6PDH, is much more effective as an inhibitor of EBV-induced transformation.