One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling.
One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling.
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DOI：
10.3390/ijms17081208
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发表时间：
2016-07-27
影响因子：
5.6
通讯作者：
Ruiz-Echevarría MJ
中科院分区：
文献类型：
--
作者：
Corbin JM;Ruiz-Echevarría MJ
癌细胞代谢与非转化细胞的代谢显著不同。这种改变的代谢重编程介导了营养物质的吸收和使用的变化，从而允许高增殖率，生长和存活。雄激素受体（AR）在前列腺癌（PCa）的形成和进展中以及在该进展期间发生的代谢适应中起重要作用。在其作为转录因子的作用中，AR直接影响基本分解代谢和生物合成途径的几种效应物和调节物的表达。作为一碳代谢的调节剂，AR可以间接影响表观遗传过程、DNA代谢和氧化还原平衡，所有这些都是肿瘤发生的重要因素。本文就AR信号通路在肿瘤发生中的作用作一综述。在这种情况下，一碳代谢和AR靶向治疗PCa的临床意义进行了讨论。
Cancer cell metabolism differs significantly from the metabolism of non-transformed cells. This altered metabolic reprogramming mediates changes in the uptake and use of nutrients that permit high rates of proliferation, growth, and survival. The androgen receptor (AR) plays an essential role in the establishment and progression of prostate cancer (PCa), and in the metabolic adaptation that takes place during this progression. In its role as a transcription factor, the AR directly affects the expression of several effectors and regulators of essential catabolic and biosynthetic pathways. Indirectly, as a modulator of the one-carbon metabolism, the AR can affect epigenetic processes, DNA metabolism, and redox balance, all of which are important factors in tumorigenesis. In this review, we focus on the role of AR-signaling on one-carbon metabolism in tumorigenesis. Clinical implications of one-carbon metabolism and AR-targeted therapies for PCa are discussed in this context.
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影响因子：
82.9
作者：
Beltran H;Prandi D;Mosquera JM;Benelli M;Puca L;Cyrta J;Marotz C;Giannopoulou E;Chakravarthi BV;Varambally S;Tomlins SA;Nanus DM;Tagawa ST;Van Allen EM;Elemento O;Sboner A;Garraway LA;Rubin MA;Demichelis F
通讯作者：
Demichelis F
影响因子：
4.7
作者：
Chen, Miao-Fen;Chen, Wen-Cheng;Wu, Chun-Te
通讯作者：
Wu, Chun-Te
影响因子：
11.2
作者：
Chen, J;Gammon, MD;Santella, RM
通讯作者：
Santella, RM
DOI：
10.1073/pnas.94.7.3290
发表时间：
1997-04-01
影响因子：
11.1
作者：
Blount, BC;Mack, MM;Ames, BN
通讯作者：
Ames, BN
影响因子：
37.3
作者：
Cao, Paul;Deng, Zhiyong;Sui, Guangchao
通讯作者：
Sui, Guangchao