Microbes taming mast cells: Implications for allergic inflammation and beyond
Microbes taming mast cells: Implications for allergic inflammation and beyond
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DOI：
10.1016/j.ejphar.2015.06.034
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发表时间：
2016-05-05
影响因子：
5
通讯作者：
Forsythe, Paul
中科院分区：
文献类型：
--
作者：
Forsythe, Paul
人们越来越意识到我们的微生物群与过敏和其他炎症性疾病的发病机制之间的关系。在研究微生物群对过敏的调节机制时，重点一直放在诱导阶段；抗原提呈细胞表型和功能的改变，调节性T细胞的诱导和Thl/Th2平衡的改变。然而，有证据表明，微生物可以影响疾病的效应期，特别是某些潜在的有益细菌可以减弱肥大细胞的活化和脱颗粒。此外，似乎不同的非致病性细菌可以利用不同的机制来稳定肥大细胞，通过与粘膜部位的肥大细胞直接相互作用或通过间接信号传导机制减弱全身肥大细胞依赖性反应来局部作用。肥大细胞在防御病原体的前线的位置也表明它们可能在促进宿主-微生物群关系中发挥重要作用。肥大细胞也是神经-免疫-内分泌交流的管道，这表明微生物调节细胞反应的能力可能对宿主生理学产生免疫学以外的影响。非致病性或共生细菌对肥大细胞调节的进一步研究可能会使我们对宿主微生物群的相互作用以及微生物群在健康和疾病中的作用有更深入的了解。(C) 2015 Elsevier B.V.版权所有
There is increasing awareness of a relationship between our microbiota and the pathogenesis of allergy and other inflammatory diseases. In investigating the mechanisms underlying microbiota modulation of allergy the focus has been on the induction phase; alterations in the phenotype and function of antigen presenting cells, induction of regulatory T cells and shifts in Thl/Th2 balance. However there is evidence that microbes can influence the effector phase of disease, specifically that certain potentially beneficial bacteria can attenuate mast cell activation and degranulation. Furthermore, it appears that different nonpathogenic bacteria can utilize distinct mechanisms to stabilize mast cells, acting locally though direct interaction with the mast cell at mucosal sites or attenuating systemic mast cell dependent responses, likely through indirect signaling mechanisms. The position of mast cells on the frontline of defense against pathogens also suggests they may play an important role in fostering the host-microbiota relationship. Mast cells are also conduits of neuro-immuo-endocrine communication, suggesting the ability of microbes to modulate cell responses may have implications for host physiology beyond immunology. Further investigation of mast cell regulation by non-pathogenic or symbiotic bacteria will likely lead to a greater understanding of host microbiota interaction and the role of the microbiome in health and disease. (C) 2015 Elsevier B.V. All rights reserved.