The Pulse‐Clamp Method for Analyzing the Electrochemistry on Neural Stimulating Electrodes
The Pulse‐Clamp Method for Analyzing the Electrochemistry on Neural Stimulating Electrodes
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神经刺激电极电化学分析的脉冲钳法
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
J. Mortimer
中科院分区：
文献类型：
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作者：
M. Bonner;M. Daroux;T. Crish;J. Mortimer
本文提出了一种脉冲钳方法，用于测量在100 μs的典型刺激脉冲时间范围内神经刺激电极上发生的电化学过程。通过立即跟随受控电流刺激脉冲并使受控电位阶跃回到刺激前电位，我们可以测量刺激脉冲期间发生的可逆反应的逆转。利用这些信息，我们可以推断出在刺激脉冲期间发生的反应以及每个过程中有多少电荷进入
A pulse-clamp method has been developed for measuring the electrochemical processes occurring on neural stimulation electrodes in the 100 μs time frame of a typical stimulus pulse. By immediately following the controlled current stimulus pulse with a controlled potential step back to the prestimulus potential, we can measure the reversal of the reversible reactions that occurred during the stimulus pulse. Using this information we can then deduce the reaction that occurred during the stimulus pulse and how much charge went into each process