Oxidation of lipids. VIII. Synergistic inhibition of oxidation of phosphatidylcholine liposome in aqueous dispersion by vitamin E and vitamin C.
Oxidation of lipids. VIII. Synergistic inhibition of oxidation of phosphatidylcholine liposome in aqueous dispersion by vitamin E and vitamin C.
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脂质的氧化。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
Y. Kamiya
中科院分区：
文献类型：
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作者：
E. Niki;A. Kawakami;Yorihiro Yamamoto;Y. Kamiya
维生素E是一种有效的抗氧化剂，用于大豆磷脂酰胆碱脂质体在水分散体中的氧化，引发氧化的自由基最初产生于水相或脂相。维生素E随时间呈线性衰减，当维生素E耗尽时，其氧化速度与没有维生素E时的氧化速度相似。维生素C本身也能有效地清除水相中的自由基，但不能有效地清除脂双层中的自由基。然而，当维生素E位于磷脂酰胆碱双层时，向水相中添加维生素C延长了氧化抑制期，并且维生素C显著降低了维生素E的衰变速度，即使自由基最初产生于脂类区域。维生素C最初主要是线性摄入的，维生素C耗尽后维生素E开始腐烂。提示维生素C可能通过与维生素E反应而再生维生素E。
Vitamin E acted as an efficient antioxidant in the oxidation of soybean phosphatidylcholine liposome in an aqueous dispersion initiated by free radicals generated initially either in the aqueous phase or in the lipid phase. Vitamin E decayed linearly with time, and when it was exhausted, the oxidation proceeded rapidly at a similar rate to that in the absence of vitamin E. Vitamin C was also effective by itself in scavenging radicals in an aqueous phase, but it could not scavenge the radicals efficiently in a lipid bilayer. However, when vitamin E was located in phosphatidylcholine bilayer, the addition of vitamin C into an aqueous phase prolonged the period of suppression of oxidation and vitamin C reduced the rate of decay of vitamin E markedly even when the radicals were generated initially in the lipid region. Vitamin C was predominantly consumed linearly at first and vitamin E began to decay after vitamin C was exhausted. It was suggested that vitamin C could regenerate vitamin E by reacting with vit...