A novel selective cooling system for the brain: feasibility study in rabbits vs piglets
A novel selective cooling system for the brain: feasibility study in rabbits vs piglets
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DOI：
10.1186/s40635-018-0211-4
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发表时间：
2018-11-01
影响因子：
3.5
通讯作者：
Lee, Ting-Yim
中科院分区：
文献类型：
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作者：
Bakhsheshi, Mohammad Fazel;Keenliside, Lynn;Lee, Ting-Yim
背景：选择性脑冷却（SBC）方法可以减轻全身低温相关的并发症。作者（MFB， LK和T-YL）开发了一种简单有效的鼻咽部SBC方法，使用涡流管。这项研究的主要重点是评估这种方法在兔子身上的有效性，并将其与我们之前发表的在仔猪身上的发现进行比较，仔猪分别是没有颈动脉网和有颈动脉网的哺乳动物。方法：对6只家兔进行实验。使用食道温度探头连续测量体温，同时使用植入的温度计测量脑温度。对每只动物进行了两次连续实验。在第一个实验中，从医院医疗出风口将室温空气以14-15 L/min的流速吹入双鼻孔，持续60分钟，开始脑冷却。第二组测量和大脑冷却的方式与第一组相同，但以相同的流速吹冷空气（-7摄氏度）。结果：以14 ~ 15 L/min的室温空气冷却1h后，脑温为34.2 +/- 1.2℃，平均脑冷却速率为3.7 +/- 0.9℃/h。脑温下降速度更快，平均速度为5.2 +/- 1.9℃/h，而食道温度探头测得的体温在冷却维持期维持在36℃以上。结论：我们已经证明使用旋涡管可以在家兔中进行初始快速和SBC。此外，仔猪和家兔之间的比较结果清楚地表明，颈动脉网的缺乏并不妨碍通过鼻咽方法对大脑进行特异性冷却。
Background: Selective brain cooling (SBC) methods could alleviate the complications associated with systemic hypothermia. The authors (MFB, LK, and T-YL) have developed a simple and an effective nasopharyngeal SBC method using a vortex tube. The primary focus of the study is to evaluate the effectiveness of this approach on rabbits and compare it with our previous published finding on piglets, which are mammals without and with a carotid rete, respectively.Methods: Experiments were conducted on six rabbits. Body temperature was measured continuously using an esophageal temperature probe while brain temperature was measured with an implanted thermometer. Two successive experiments were performed on each animal. In the first experiment, brain cooling was initiated by blowing room temperature air from the hospital medical air outlet, at a flow rate of 14-15 L/min into both nostrils for 60 min. The second series of measurements and brain cooling was performed in the same manner as the first one but blowing cold air (-7 degrees C) at the same flow rate.Results: One hour post cooling with room temperature air at a flow rate of 14-15 L/min,the brain temperature was 34.2 +/- 1.2 degrees C which resulted in mean brain cooling rates of 3.7 +/- 0.9 degrees C/h. Brain temperature could be reduced more rapidly at mean rates of 5.2 +/- 1.9 degrees C/h, while the body temperature as measured by the esophageal temperature probe was maintained above 36 degrees C during cooling and maintaining period.Conclusions: We have demonstrated that using the vortex tube allows initial rapid and SBC in rabbits. Moreover, comparing results between piglets and rabbits demonstrates clearly that the lack of a carotid rete does not prevent specific cooling of the brain by means of the nasopharyngeal method.