A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates
A novel class of antagonists for metabotropic glutamate receptors, 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylates
复制标题
DOI：
10.1016/0960-894x(96)00104-7
复制
发表时间：
1996-04-09
影响因子：
2.7
通讯作者：
Horikawa, Y
中科院分区：
文献类型：
--
作者：
Annoura, H;Fukunaga, A;Horikawa, Y
7-（羟基亚氨基）环丙烯并[B]苯并吡喃-1a-羧酸酯（4a-c）是磷脂酶C连接的代谢型谷氨酸受体mGluR 1的高效拮抗剂，其通过使用二甲基氧硫鎓甲立德环丙烷化到4-氧代-4H-1-苯并吡喃-2-羧酸酯（5a-c）上，然后用羟胺处理来合成。版权所有（C）1996 Elsevier Science Ltd
7-(Hydroxyimino)cyclopropa[b] chromen-1a-carboxylates (4a-c), highly potent antagonists for a phospholipase C-linked metabotropic glutamate receptor, mGluR1, were synthesized through cyclopropanation onto 4-oxo-4H-1-benzopyran-2-carboxylates (5a-c) utilizing dimethyloxosulfonium methylid followed by treatment with hydroxylamine. Copyright (C) 1996 Elsevier Science Ltd