Incidence of herpes simplex virus type 2 infection in the United States
Incidence of herpes simplex virus type 2 infection in the United States
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DOI：
10.1093/aje/153.9.912
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发表时间：
2001-05-01
影响因子：
5
通讯作者：
St Louis, ME
中科院分区：
文献类型：
--
作者：
Armstrong, GL;Schillinger, J;St Louis, ME
在进行两次大型全国性调查（第二次全国健康和营养检查调查（1976-1980）和第三次全国健康和营养检查调查（1988-1994））期间，美国单纯疱疹病毒2型（HSV-2）感染的患病率增加了30%。根据这些调查数据，作者通过一个数学模型估计了年龄大于或等于12岁的平民、非机构化人群中HSV-2感染的发病率，该模型允许总体发病率随时间线性增加，但要求年龄特异性发病率曲线的形状保持不变。从1970年到1985年，HSV-2血清阴性人群中HSV-2感染的年发病率增加了82%，从4.6/1000（95%置信区间：4.2，5.0）增加到8.4/1000（95%置信区间：7.7，9.1）。1985年，妇女的发病率高于男子（每1 000人中有9.9人对6.9人），黑人高于白人（每1 000人中有20.4人对6.3人），20-29岁年龄组的发病率最高（男子和妇女分别为每1 000人中有14.6人和22.5人）。因此，到1985年，每年约有1，640，000 +/-150，000人（730，000名男性和910，000名女性）感染HSV-2。
Between the time that two large, national surveys were conducted, the Second National Health and Nutrition Examination Survey (1976-1980) and the Third National Health and Nutrition Examination Survey (1988-1994), prevalence of herpes simplex virus type 2 (HSV-2) infection in the United States increased by 30%. From these survey data, the authors estimated the incidence of HSV-2 infection in the civilian, noninstitutionalized population aged greater than or equal to 12 years by means of a mathematical model that allowed overall incidence to increase linearly with time but required the shape of the age-specific incidence curve to remain constant. From 1970 to 1985, annual incidence of HSV-2 infection in HSV-2-seronegative persons increased by 82%, from 4.6 per 1,000 (95% confidence interval: 4.2, 5.0) to 8.4 per 1,000 (95% confidence interval: 7.7, 9.1). Incidence in 1985 was higher in women than in men (9.9 vs. 6.9 per 1,000), higher in Blacks than in Whites (20.4 vs. 6.3 per 1,000), and highest in the group aged 20-29 years (14.6 and 22.5 per 1,000 in men and women, respectively). Thus, by 1985, approximately 1,640,000 +/- 150,000 persons (730,000 men and 910,000 women) were being infected annually with HSV-2.