Enantioselective total synthesis of (-)-nardoaristolone B via a gold(I)-catalyzed oxidative cyclization.
Enantioselective total synthesis of (-)-nardoaristolone B via a gold(I)-catalyzed oxidative cyclization.
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DOI：
10.1021/ol503531n
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发表时间：
2015-02-06
期刊：
影响因子：
5.2
通讯作者：
Echavarren AM
中科院分区：
文献类型：
--
作者：
Homs A;Muratore ME;Echavarren AM
通过实施首次用于全合成的对映体和非对映体选择性铜（I）催化的共轭加成/烯醇化物捕获序列和金（I）催化的氧化环化（分子间氧化剂），完成了（-）-纳多马兜铃酮B的首次对映体选择性全合成。
The first enantioselective total synthesis of (−)-nardoaristolone B is accomplished by the implementation of an enantio- and diastereoselective copper(I)-catalyzed conjugate addition/enolate trapping sequence and a gold(I)-catalyzed oxidative cyclization (intermolecular oxidant), employed for the first time in total synthesis.