Transcriptional Profiling of Mycobacterium tuberculosis Replicating in the Human Type II Alveolar Epithelial Cell Line, A549.
Transcriptional Profiling of Mycobacterium tuberculosis Replicating in the Human Type II Alveolar Epithelial Cell Line, A549.
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DOI：
10.1016/j.gdata.2015.05.026
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发表时间：
2015-09-01
期刊：
影响因子：
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通讯作者：
Laal S
中科院分区：
文献类型：
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作者：
Ryndak MB;Singh KK;Peng Z;Laal S
肺泡上皮细胞的数量超过肺泡巨噬细胞约500倍，并且越来越多的证据表明，结核分枝杆菌在感染肺的最初几周期间可以在这些细胞中显著复制（Wolf等人，2008 [1]; Ryndak等人，2015 [2]）。在这里，我们报告的实验细节的转录谱M。结核分枝杆菌在感染后72小时在人II型肺泡上皮细胞系A549中复制，与M.结核病在实验室肉汤培养物中快速生长（Ryndak等人，2015 [2]）。将所有所得的转录谱数据以登录号GSE 58466保存到基因表达综合（GEO）数据库中。
Alveolar epithelial cells outnumber alveolar macrophages by ~ 500 fold and increasing evidence suggests that Mycobacterium tuberculosis may replicate dramatically in these cells during the initial weeks of infecting the lung (Wolf et al., 2008 [1]; Ryndak et al., 2015 [2]). Here, we report in experimental detail the transcriptional profiling of M. tuberculosis replicating at 72 h post-infection in the human type II alveolar epithelial cell line, A549, as compared to M. tuberculosis growing logarithmically in laboratory broth culture (Ryndak et al., 2015 [2]). All resulting transcriptional profiling data was deposited to the Gene Expression Omnibus (GEO) database under the accession number GSE58466.