Increase of fucosylated alpha-fetoprotein fraction at the onset of autoimmune hepatitis and acute liver failure
Increase of fucosylated alpha-fetoprotein fraction at the onset of autoimmune hepatitis and acute liver failure
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DOI：
10.1111/hepr.12318
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发表时间：
2014-12-01
影响因子：
4.2
通讯作者：
Aoyagi, Yutaka
中科院分区：
文献类型：
--
作者：
Yamagiwa, Satoshi;Tamura, Yasushi;Aoyagi, Yutaka
目的血清-胎儿蛋白（AFP）的升高与急性肝衰竭（ALF）后的良好预后相关，但急性肝损伤后AFP的聚焦部分（Lens culinaris凝集素反应部分[AFP- l3]）的水平尚不清楚。本研究旨在探讨急性肝损伤患者AFP及AFP- l3的临床意义。方法采用高灵敏免疫分析法（微总量分析系统）检测27例急性自身免疫性肝炎（AIH）、28例急性肝炎（AH）和22例ALF患者发病时血清AFP和高敏感AFP- l3%的水平。结果AIH、AH和ALF患者血清AFP水平均升高，但三者间差异无统计学意义。然而，AIH患者的平均AFP-L3%水平明显高于AH患者（P=0.0039）。此外，AIH患者AFP-L3阳性（10%）明显高于AH患者（P=0.014）。虽然AFP- l3阳性百分比随AFP水平升高而升高，但在血清AFP水平低时(
AimIncreased serum -fetoprotein (AFP) has been associated with a good prognosis following acute liver failure (ALF), but the levels of the fucosylated fraction of AFP (Lens culinaris agglutinin-reactive fraction of AFP [AFP-L3]) following acute liver injury remain unknown. The aim of the present study was to investigate the clinical significance of AFP and AFP-L3 in patients with acute liver injury.MethodsWe investigated the serum levels of AFP and highly sensitive AFP-L3% in 27 patients with acute-onset autoimmune hepatitis (AIH), 28 patients with acute hepatitis (AH) and 22 patients with ALF at the onset using a highly sensitive immunoassay (micro-total analysis system).ResultsThe serum AFP levels were increased in patients with AIH, AH and ALF, but the levels did not significantly differ among them. However, the mean AFP-L3% level was significantly higher in patients with AIH than in patients with AH (P=0.0039). Moreover, significantly more patients with AIH demonstrated AFP-L3 positivity (10%) when compared with patients with AH (P=0.014). Although the percentage of AFP-L3 positivity increased with AFP levels, at low serum AFP levels (