Improving theranostics in pancreatic cancer.
Improving theranostics in pancreatic cancer.
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DOI：
10.1002/jso.24625
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发表时间：
2017-07
影响因子：
2.5
通讯作者：
Williams J
中科院分区：
文献类型：
--
作者：
King J;Bouvet M;Singh G;Williams J
胰腺癌是美国第四大致命癌症，预计到 2030 年将成为第二大致命癌症。治疗胰腺癌的主要困难是症状出现较晚。一般来说，患者在诊断时已出现转移性疾病，5年后生存率为5%。对于没有转移性疾病的患者，手术切除可将 5 年生存率提高至 25%。其余 75% 死于未检测到的转移。显然，需要改进检测、手术干预和治疗策略，以改善胰腺癌患者的预后。对最近的文献进行了调查，并生成了新治疗方法的原子模型。在这里，我们重点关注利用单克隆抗体 (mAb) 靶向胰腺癌相关标志物的最新进展，更具体地说，重点关注最近在化学和蛋白质工程方面所做的努力，以提高 mAb 的均质性、稳定性和给药方式，以将显像剂和细胞毒素精确递送至疾病部位。
Pancreatic cancer is the fourth most deadly cancer in the US, and is expected to be the second most deadly by 2030. The major difficulty in treating pancreatic cancer is the late onset of symptoms. Generally, patients show metastatic disease by the time of diagnosis, with a survival rate of 5% beyond 5 years. In patients without metastatic disease, surgical resection increases 5 year survival rate to 25%. The remaining 75% succumb to undetected metastases. Clearly, improvements to both detection, surgical intervention, and therapeutic strategies will be needed to improve patient outcome in pancreatic cancer. Recent literature has been surveyed and atomic models of new therapeutic appoaches were generated. Here, we focus on the recent progress employing monoclonal antibodies (mAbs) to target pancreatic cancer associated markers, and more specifically on recent chemical and protein engineering efforts to improve the homogeneity, stability, and administration of mAbs to precisely delivery imaging agents and cytotoxins to sites of disease.
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影响因子：
16
作者：
Sablin, EP;Krylova, IN;Ingraham, HA
通讯作者：
Ingraham, HA
DOI：
10.1073/pnas.1112047108
发表时间：
2011-10-11
影响因子：
11.1
作者：
Benod, Cindy;Vinogradova, Maia V.;Sablin, Elena P.
通讯作者：
Sablin, Elena P.
影响因子：
3.7
作者：
de Jesus Cortez F;Suzawa M;Irvy S;Bruning JM;Sablin E;Jacobson MP;Fletterick RJ;Ingraham HA;England PM
通讯作者：
England PM
影响因子：
16
作者：
Botrugno, OA;Fayard, E;Schoonjans, K
通讯作者：
Schoonjans, K
影响因子：
7.5
作者：
Stein, Sokrates;Schoonjans, Kristina
通讯作者：
Schoonjans, Kristina