Immunoelectronmicroscopic localization of IgA in skin of patients with dermatitis herpetiformis.
Immunoelectronmicroscopic localization of IgA in skin of patients with dermatitis herpetiformis.
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疱疹样皮炎患者皮肤中 IgA 的免疫电镜定位。
DOI：
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发表时间：
1976
影响因子：
6.5
通讯作者：
S. Katz
中科院分区：
文献类型：
--
作者：
H. Yaoita;S. Katz
使用改良的过氧化物酶-抗过氧化物酶多步法测定了疱疹样皮炎患者皮肤中体内结合 IgA 的超微结构定位。可以看到三种类型的反应产物沉积。最常见的反应产物沉积类型，通过直接免疫荧光鉴定为斑点型 IgA 沉积，表现为团块和纱线状原纤维。第二种类型的 IgA 沉积是直接免疫荧光检测的线性条带，似乎与锚定原纤维有关。第三个 IgA 沉积（通过免疫荧光检测也是线性的）仅限于透明层。
Ultrastructural localization of in vivo-bound IgA in the skin of patients with dermatitis herpetiformis was determined by using a modified peroxidase-antiperoxidase multistep method. Three types of reaction product deposition are seen. The most common type of reaction product deposition, that which is identified by direct immunofluorescence as the speckled type of IgA deposit, shows up as clumps and yarnlike fibrils. The second type of IgA deposition, which is a linear band by direct immunofluorescence, appears to be associated with anchoring fibrils. The third of IgA deposition, which is also linear by immunofluorescence, is confined to the lamina lucida.