Aberrant default mode network in subjects with amnestic mild cognitive impairment using resting-state functional MRI.
Aberrant default mode network in subjects with amnestic mild cognitive impairment using resting-state functional MRI.
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DOI：
10.1016/j.mri.2011.07.007
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发表时间：
2012-01
影响因子：
2.5
通讯作者：
Cordes, Dietmar
中科院分区：
文献类型：
--
作者：
Jin, Mingwu;Pelak, Victoria S.;Cordes, Dietmar
关键词：
遗忘性轻度认知障碍（aMCI）是一种与记忆衰退比正常衰老更快相关的综合征，通常代表阿尔茨海默病的前驱期。当一个人没有积极参与目标导向的任务时，自发功能磁共振成像（fMRI）信号可以揭示功能连接的大脑网络，包括所谓的默认模式网络（DMN）。迄今为止，只有少数研究调查了aMCI人群的DMN功能。本研究对8名aMCI患者和8名正常对照组的静息状态fMRI数据进行了组独立分量分析，获得了垂直于海马长轴的切片。与正常对照组相比，aMCI患者在中扣带皮层、内侧前额叶皮层和左侧顶叶下皮层的DMN活性增加。与正常对照组相比，aMCI组的外侧前额叶皮层、左侧内侧颞叶（MTL）、左侧内侧颞回、后扣带皮层/脾后皮层/楔前叶和右侧角回的DMN活性下降。虽然两组间MTL体积差异无统计学意义，但aMCI组左MTL活性降低。左外侧前额叶皮层、左内侧颞回和右角回的DMN活动与记忆评分呈正相关。这些发现支持了这样一个前提，即DMN的改变发生在aMCI中，可能表明与记忆功能相关的功能性、内在脑结构的缺陷，甚至在结构MRI检测到显著的内侧颞叶萎缩之前。
Amnestic mild cognitive impairment (aMCI) is a syndrome associated with faster memory decline than normal aging, and frequently represents the prodromal phase of Alzheimer’s disease. When a person is not actively engaged in a goal-directed task, spontaneous functional magnetic resonance imaging (fMRI) signals can reveal functionally connected brain networks, including the so-called default mode network (DMN). To date, only a few studies have investigated DMN functions in aMCI populations. In this study, group independent component analysis was conducted for resting-state fMRI data, with slices acquired perpendicular to the long axis of the hippocampus, from eight subjects with aMCI and eight normal control subjects. Subjects with aMCI showed increased DMN activity in middle cingulate cortex, medial prefrontal cortex, and left inferior parietal cortex compared to the normal control group. Decreased DMN activity for the aMCI group compared to the normal control group was noted in lateral prefrontal cortex, left medial temporal lobe (MTL), left medial temporal gyrus, posterior cingulate cortex/retrosplenial cortex/precuneus, and right angular gyrus. Although MTL volume difference between the two groups was not statistical significant, decreased activity in left MTL was observed for the aMCI group. Positive correlations between DMN activity and memory scores were noted for left lateral prefrontal cortex, left medial temporal gyrus, and right angular gyrus. These findings support the premise that alterations of the DMN occur in aMCI and may indicate deficiencies in functional, intrinsic brain architecture, that correlate with memory function, even before significant medial temporal lobe atrophy is detectable by structural MRI.
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