Curative radiotherapy for localized diffuse histiocytic lymphoma.
Curative radiotherapy for localized diffuse histiocytic lymphoma.
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局部弥漫性组织细胞淋巴瘤的根治性放射治疗。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
C. K. Lee
中科院分区：
文献类型：
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作者：
S. Levitt;C. Bloomfield;G. Frizzera;C. K. Lee
10例新诊断的局部弥漫性组织细胞性淋巴瘤患者根据Lukes-Collins分类法进行分类，评价其对扩展野放射治疗的反应。所有分类的肿瘤均为滤泡中心细胞类型（四个大分裂、四个大无分裂和一个小无分裂）。有9名患者患有I期疾病，1名患者患有II期疾病。II期疾病的患者只有两个部位受累。6例为结节性，4例为结节性。所有患者均存活，自诊断后19至102个月无疾病复发证据（中位生存期，58 +个月）。组织学分类之间的缓解率或生存率无差异。未发生明显的即刻或长期并发症。这些结果表明，单纯放疗是治疗局限性弥漫性组织细胞淋巴瘤，并可能是上级最近提倡的化疗方法。
Ten newly diagnosed patients, with localized diffuse histiocytic lymphoma classified according to the Lukes-Collins classification, were evaluated for response to treatment with extended-field radiation. All classified tumors were of follicular center cell type (four large cleaved, four large noncleaved, and one small noncleaved). There were nine patients with stage I disease and one with stage II disease. The patient with stage II disease had only two sites of involvement. The disease was nodal in six patients and extranodal in four. All patients are alive without evidence of disease recurrence from 19 to 102 months since diagnosis (median survival, 58 + months). No differences were found in response or survival rates between histologic categories. No significant immediate or long-term complications have occurred. These results suggest that radiotherapy alone is curative for localized diffuse histiocytic lymphoma and may be superior to recently advocated chemotherapeutic approaches.