Vascular cell adhesion molecule 1 predicts cancer-free survival in clear cell renal carcinoma patients
Vascular cell adhesion molecule 1 predicts cancer-free survival in clear cell renal carcinoma patients
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DOI：
10.1158/1078-0432.ccr-06-1737
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发表时间：
2006-12-15
影响因子：
11.5
通讯作者：
Yao, Masahiro
中科院分区：
文献类型：
--
作者：
Shioi, Ko-ichi;Komiya, Atsushi;Yao, Masahiro
目的：血管细胞粘附分子1（VCAM 1）是一种细胞表面糖蛋白，参与多种病理生理过程。我们测量肿瘤组织中VCAM 1的表达水平，并评估其意义和预后的使用在肾细胞癌（RCC）。实验设计：我们使用实时定量PCR检测VCAM 1的表达水平共485散发性肾肿瘤，包括429透明细胞，乳头状21，17嫌色细胞，11嗜酸细胞瘤，7集合管癌。我们回顾性研究了这种表达与各种临床病理变量和von Hippel-Lindau改变状态的关系。我们评估其意义与患者的生存率结合使用的考克斯回归模型与分裂-sample method.Results：与正常肾脏样本（n = 43）相比，VCAM 1在透明细胞肾细胞癌和乳头状肾细胞癌显着上调，而它在嫌色肾细胞癌和嗜酸细胞瘤下调。在透明细胞RCC中，VCAM 1表达水平在表现时无症状的患者和具有小肿瘤尺寸、低阶段、低级别、微血管浸润阴性和von Hippel-Lindau改变阳性肿瘤的患者中明显高。单变量分析显示，VCAM 1高表达与透明细胞和乳头状RCC的预后良好密切相关。此外，考克斯多变量分析模型结合分裂样本的方法显示，这种关联是显着的，只有在无癌生存透明细胞肾细胞癌患者根治性手术切除术后。结论：VCAM 1表达水平被发现是组织学亚型特异性肾肿瘤。VCAM 1表达水平作为生物标志物的测定可以为透明细胞RCC患者提供有用的预后信息。
Purpose: Vascular cell adhesion molecule 1 (VCAM1) is a cell surface glycoprotein implicated in various pathophysiologic conditions. We measured VCAM1 expression levels in tumor tissues and evaluated its significance and prognostic use in renal cell carcinoma (RCC).Experimental Design: We used real-time quantitative PCR to examine the VCAM1 expression levels of a total of 485 sporadic renal tumors, including 429 clear cell, 21 papillary, 17 chromophobe, 11 oncocytomas, and 7 collecting duct carcinomas. We retrospectively examined the relationship of this expression to various clinicopathologic variables and the von Hippel-Lindau alteration status. We evaluated its significance with respect to patient survival rates using the Cox regression model combined with the split-sample method.Results: Compared with normal kidney samples (n = 43), VCAM1 was significantly up-regulated in clear cell RCC and papillary RCC, whereas it was down-regulated in chromophobe RCC and oncocytoma. In clear cell RCC, VCAM1 expression levels were apparently high in patients asymptomatic at presentation and in patients with small tumor size, low-stage, low-grade, microvascular invasion - negative, and von Hippel-Lindau alteration-positive tumors. Univariate analyses showed that VCAM1 high expression is strongly associated with better outcomes in clear cell and papillary RCCs. Further, Cox multivariate analysis models combined with the split-sample method revealed that this association is significant only in cancer-free survival for patients with clear cell RCC after curative surgical resection.Conclusions: VCAM1 expression levels were found to be histologically subtype specific in renal tumors. Determination of the VCAM1 expression level as a biomarker can provide useful prognostic information for patients with clear cell RCC.